Telomeric RNAs as a novel player in telomeric integrity

Telomeres protect linear chromosome ends from being recognized and processed as double-strand breaks by DNA repair activities. This protective function of telomeres is essential for chromosome stability. Until recently, telomeres have been considered to be transcriptionally silent. This notion was o...

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Detalles Bibliográficos
Autores principales: Isken, Olaf, Maquat, Lynne E
Formato: Texto
Lenguaje:English
Publicado: Biology Reports Ltd 2009
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849317/
https://www.ncbi.nlm.nih.gov/pubmed/20376293
http://dx.doi.org/10.3410/B1-90
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author Isken, Olaf
Maquat, Lynne E
author_facet Isken, Olaf
Maquat, Lynne E
author_sort Isken, Olaf
collection PubMed
description Telomeres protect linear chromosome ends from being recognized and processed as double-strand breaks by DNA repair activities. This protective function of telomeres is essential for chromosome stability. Until recently, telomeres have been considered to be transcriptionally silent. This notion was overturned in a series of recent papers that describe the existence of telomeric repeat-containing RNAs (TERRAs) in vertebrates and yeast. Here, we summarize recent developments in this field of telomere research, in particular the possible mechanisms that control TERRA expression.
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spelling pubmed-28493172010-10-14 Telomeric RNAs as a novel player in telomeric integrity Isken, Olaf Maquat, Lynne E F1000 Biol Rep Review Article Telomeres protect linear chromosome ends from being recognized and processed as double-strand breaks by DNA repair activities. This protective function of telomeres is essential for chromosome stability. Until recently, telomeres have been considered to be transcriptionally silent. This notion was overturned in a series of recent papers that describe the existence of telomeric repeat-containing RNAs (TERRAs) in vertebrates and yeast. Here, we summarize recent developments in this field of telomere research, in particular the possible mechanisms that control TERRA expression. Biology Reports Ltd 2009-11-26 /pmc/articles/PMC2849317/ /pubmed/20376293 http://dx.doi.org/10.3410/B1-90 Text en © 2009 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Isken, Olaf
Maquat, Lynne E
Telomeric RNAs as a novel player in telomeric integrity
title Telomeric RNAs as a novel player in telomeric integrity
title_full Telomeric RNAs as a novel player in telomeric integrity
title_fullStr Telomeric RNAs as a novel player in telomeric integrity
title_full_unstemmed Telomeric RNAs as a novel player in telomeric integrity
title_short Telomeric RNAs as a novel player in telomeric integrity
title_sort telomeric rnas as a novel player in telomeric integrity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849317/
https://www.ncbi.nlm.nih.gov/pubmed/20376293
http://dx.doi.org/10.3410/B1-90
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