The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals

The thymus is the major site of T cell production and a key organ of the immune system. Its natural involution during the course of life has cast doubts as to its importance for the integrity of our immunity in adulthood. We provide here an overview of the recent works focusing on the immunological...

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Detalles Bibliográficos
Autores principales: Appay, Victor, Sauce, Delphine, Prelog, Martina
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850143/
https://www.ncbi.nlm.nih.gov/pubmed/20354268
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author Appay, Victor
Sauce, Delphine
Prelog, Martina
author_facet Appay, Victor
Sauce, Delphine
Prelog, Martina
author_sort Appay, Victor
collection PubMed
description The thymus is the major site of T cell production and a key organ of the immune system. Its natural involution during the course of life has cast doubts as to its importance for the integrity of our immunity in adulthood. We provide here an overview of the recent works focusing on the immunological evaluation of subjects thymectomized during early childhood due to cardiac surgery of congenital heart defects. These studies represent new advances in our appreciation of the role of the thymus in humans and more generally in our understanding of the development of immunosenescence.
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spelling pubmed-28501432010-04-07 The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals Appay, Victor Sauce, Delphine Prelog, Martina Aging (Albany NY) Review The thymus is the major site of T cell production and a key organ of the immune system. Its natural involution during the course of life has cast doubts as to its importance for the integrity of our immunity in adulthood. We provide here an overview of the recent works focusing on the immunological evaluation of subjects thymectomized during early childhood due to cardiac surgery of congenital heart defects. These studies represent new advances in our appreciation of the role of the thymus in humans and more generally in our understanding of the development of immunosenescence. Impact Journals LLC 2010-02-17 /pmc/articles/PMC2850143/ /pubmed/20354268 Text en Copyright: ©2010 Appay et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Appay, Victor
Sauce, Delphine
Prelog, Martina
The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
title The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
title_full The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
title_fullStr The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
title_full_unstemmed The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
title_short The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
title_sort role of the thymus in immunosenescence: lessons from the study of thymectomized individuals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850143/
https://www.ncbi.nlm.nih.gov/pubmed/20354268
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