Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats

We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark)...

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Autores principales: Vinogradova, Irina A., Anisimov, Vladimir N., Bukalev, Andrey V., Ilyukha, Viktor A., Khizhkin, Evgeniy A., Lotosh, Tatiana A., Semenchenko, Anna V., Zabezhinski, Mark A.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850144/
https://www.ncbi.nlm.nih.gov/pubmed/20354269
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author Vinogradova, Irina A.
Anisimov, Vladimir N.
Bukalev, Andrey V.
Ilyukha, Viktor A.
Khizhkin, Evgeniy A.
Lotosh, Tatiana A.
Semenchenko, Anna V.
Zabezhinski, Mark A.
author_facet Vinogradova, Irina A.
Anisimov, Vladimir N.
Bukalev, Andrey V.
Ilyukha, Viktor A.
Khizhkin, Evgeniy A.
Lotosh, Tatiana A.
Semenchenko, Anna V.
Zabezhinski, Mark A.
author_sort Vinogradova, Irina A.
collection PubMed
description We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accelerated spontaneous tumorigenesis and shortened life span both in male and female rats as compared to the standard regimen. At the same time, the exposure to constant light started at the age of 14 months failed to influence survival of male and female rats. While delaying tumors in males, constant light accelerated tumors in females. We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months.
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spelling pubmed-28501442010-04-07 Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats Vinogradova, Irina A. Anisimov, Vladimir N. Bukalev, Andrey V. Ilyukha, Viktor A. Khizhkin, Evgeniy A. Lotosh, Tatiana A. Semenchenko, Anna V. Zabezhinski, Mark A. Aging (Albany NY) Research Article We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accelerated spontaneous tumorigenesis and shortened life span both in male and female rats as compared to the standard regimen. At the same time, the exposure to constant light started at the age of 14 months failed to influence survival of male and female rats. While delaying tumors in males, constant light accelerated tumors in females. We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months. Impact Journals LLC 2010-03-04 /pmc/articles/PMC2850144/ /pubmed/20354269 Text en Copyright: ©2010 Vinogradova et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vinogradova, Irina A.
Anisimov, Vladimir N.
Bukalev, Andrey V.
Ilyukha, Viktor A.
Khizhkin, Evgeniy A.
Lotosh, Tatiana A.
Semenchenko, Anna V.
Zabezhinski, Mark A.
Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats
title Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats
title_full Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats
title_fullStr Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats
title_full_unstemmed Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats
title_short Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats
title_sort circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850144/
https://www.ncbi.nlm.nih.gov/pubmed/20354269
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