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Viral Vaccines and CTL Response
Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The task of exerting antipathogen activity by CD8+ T...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850151/ https://www.ncbi.nlm.nih.gov/pubmed/20379365 http://dx.doi.org/10.1155/2010/141657 |
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author | Woolard, Stacie N. Kumaraguru, Uday |
author_facet | Woolard, Stacie N. Kumaraguru, Uday |
author_sort | Woolard, Stacie N. |
collection | PubMed |
description | Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The task of exerting antipathogen activity by CD8+ T cells, which principally function to control and eradicate intracellular pathogens, is enabled by constitutive expression of MHC class-I molecules on all tissue types. CTL induction offers hope for vaccines against pathogens that are resistant to neutralizing activity. This review discusses the mechanism of immune induction by some successful vaccines and based on the accrued evidence suggests ideas for improved design of CTL-inducing vaccines. |
format | Text |
id | pubmed-2850151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28501512010-04-08 Viral Vaccines and CTL Response Woolard, Stacie N. Kumaraguru, Uday J Biomed Biotechnol Review Article Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The task of exerting antipathogen activity by CD8+ T cells, which principally function to control and eradicate intracellular pathogens, is enabled by constitutive expression of MHC class-I molecules on all tissue types. CTL induction offers hope for vaccines against pathogens that are resistant to neutralizing activity. This review discusses the mechanism of immune induction by some successful vaccines and based on the accrued evidence suggests ideas for improved design of CTL-inducing vaccines. Hindawi Publishing Corporation 2010 2010-03-31 /pmc/articles/PMC2850151/ /pubmed/20379365 http://dx.doi.org/10.1155/2010/141657 Text en Copyright © 2010 S. N. Woolard and U. Kumaraguru. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Woolard, Stacie N. Kumaraguru, Uday Viral Vaccines and CTL Response |
title | Viral Vaccines and CTL Response |
title_full | Viral Vaccines and CTL Response |
title_fullStr | Viral Vaccines and CTL Response |
title_full_unstemmed | Viral Vaccines and CTL Response |
title_short | Viral Vaccines and CTL Response |
title_sort | viral vaccines and ctl response |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850151/ https://www.ncbi.nlm.nih.gov/pubmed/20379365 http://dx.doi.org/10.1155/2010/141657 |
work_keys_str_mv | AT woolardstacien viralvaccinesandctlresponse AT kumaraguruuday viralvaccinesandctlresponse |