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Viral Vaccines and CTL Response

Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The task of exerting antipathogen activity by CD8+ T...

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Detalles Bibliográficos
Autores principales: Woolard, Stacie N., Kumaraguru, Uday
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850151/
https://www.ncbi.nlm.nih.gov/pubmed/20379365
http://dx.doi.org/10.1155/2010/141657
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author Woolard, Stacie N.
Kumaraguru, Uday
author_facet Woolard, Stacie N.
Kumaraguru, Uday
author_sort Woolard, Stacie N.
collection PubMed
description Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The task of exerting antipathogen activity by CD8+ T cells, which principally function to control and eradicate intracellular pathogens, is enabled by constitutive expression of MHC class-I molecules on all tissue types. CTL induction offers hope for vaccines against pathogens that are resistant to neutralizing activity. This review discusses the mechanism of immune induction by some successful vaccines and based on the accrued evidence suggests ideas for improved design of CTL-inducing vaccines.
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spelling pubmed-28501512010-04-08 Viral Vaccines and CTL Response Woolard, Stacie N. Kumaraguru, Uday J Biomed Biotechnol Review Article Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The task of exerting antipathogen activity by CD8+ T cells, which principally function to control and eradicate intracellular pathogens, is enabled by constitutive expression of MHC class-I molecules on all tissue types. CTL induction offers hope for vaccines against pathogens that are resistant to neutralizing activity. This review discusses the mechanism of immune induction by some successful vaccines and based on the accrued evidence suggests ideas for improved design of CTL-inducing vaccines. Hindawi Publishing Corporation 2010 2010-03-31 /pmc/articles/PMC2850151/ /pubmed/20379365 http://dx.doi.org/10.1155/2010/141657 Text en Copyright © 2010 S. N. Woolard and U. Kumaraguru. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Woolard, Stacie N.
Kumaraguru, Uday
Viral Vaccines and CTL Response
title Viral Vaccines and CTL Response
title_full Viral Vaccines and CTL Response
title_fullStr Viral Vaccines and CTL Response
title_full_unstemmed Viral Vaccines and CTL Response
title_short Viral Vaccines and CTL Response
title_sort viral vaccines and ctl response
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850151/
https://www.ncbi.nlm.nih.gov/pubmed/20379365
http://dx.doi.org/10.1155/2010/141657
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