Genome-wide association study of PR interval

The electrocardiographic PR interval reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation (AF). To identify underlying common genetic variation, we meta-analyzed genome-wide association results for PR interval from seven community-based st...

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Autores principales: Pfeufer, Arne, van Noord, Charlotte, Marciante, Kristin D., Arking, Dan E., Larson, Martin G., Smith, Albert Vernon, Tarasov, Kirill V., Müller, Martina, Sotoodehnia, Nona, Sinner, Moritz F., Verwoert, Germaine C., Li, Man, Kao, W.H. Linda, Köttgen, Anna, Coresh, Josef, Bis, Joshua C., Psaty, Bruce M., Rice, Kenneth, Rotter, Jerome I., Rivadeneira, Fernando, Hofman, Albert, Kors, Jan A., Stricker, Bruno H.C., Uitterlinden, André G., van Duijn, Cornelia M., Beckmann, Britt M., Sauter, Wiebke, Gieger, Christian, Lubitz, Steven A., Newton-Cheh, Christopher, Wang, Thomas J., Magnani, Jared W., Schnabel, Renate B., Chung, Mina K., Barnard, John, Smith, Jonathan D., Van Wagoner, David R., Vasan, Ramachandran S., Aspelund, Thor, Eiriksdottir, Gudny, Harris, Tamara B., Launer, Lenore J., Najjar, Samer S., Lakatta, Edward, Schlessinger, David, Uda, Manuela, Abecasis, Gonçalo R., Müller-Myhsok, Bertram, Ehret, Georg B., Boerwinkle, Eric, Chakravarti, Aravinda, Soliman, Elsayed Z., Lunetta, Kathryn L., Perz, Siegfried, Wichmann, H.-Erich, Meitinger, Thomas, Levy, Daniel, Gudnason, Vilmundur, Ellinor, Patrick T., Sanna, Serena, Kääb, Stefan, Witteman, Jacqueline C.M., Alonso, Alvaro, Benjamin, Emelia J., Heckbert, Susan R.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850197/
https://www.ncbi.nlm.nih.gov/pubmed/20062060
http://dx.doi.org/10.1038/ng.517
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author Pfeufer, Arne
van Noord, Charlotte
Marciante, Kristin D.
Arking, Dan E.
Larson, Martin G.
Smith, Albert Vernon
Tarasov, Kirill V.
Müller, Martina
Sotoodehnia, Nona
Sinner, Moritz F.
Verwoert, Germaine C.
Li, Man
Kao, W.H. Linda
Köttgen, Anna
Coresh, Josef
Bis, Joshua C.
Psaty, Bruce M.
Rice, Kenneth
Rotter, Jerome I.
Rivadeneira, Fernando
Hofman, Albert
Kors, Jan A.
Stricker, Bruno H.C.
Uitterlinden, André G.
van Duijn, Cornelia M.
Beckmann, Britt M.
Sauter, Wiebke
Gieger, Christian
Lubitz, Steven A.
Newton-Cheh, Christopher
Wang, Thomas J.
Magnani, Jared W.
Schnabel, Renate B.
Chung, Mina K.
Barnard, John
Smith, Jonathan D.
Van Wagoner, David R.
Vasan, Ramachandran S.
Aspelund, Thor
Eiriksdottir, Gudny
Harris, Tamara B.
Launer, Lenore J.
Najjar, Samer S.
Lakatta, Edward
Schlessinger, David
Uda, Manuela
Abecasis, Gonçalo R.
Müller-Myhsok, Bertram
Ehret, Georg B.
Boerwinkle, Eric
Chakravarti, Aravinda
Soliman, Elsayed Z.
Lunetta, Kathryn L.
Perz, Siegfried
Wichmann, H.-Erich
Meitinger, Thomas
Levy, Daniel
Gudnason, Vilmundur
Ellinor, Patrick T.
Sanna, Serena
Kääb, Stefan
Witteman, Jacqueline C.M.
Alonso, Alvaro
Benjamin, Emelia J.
Heckbert, Susan R.
author_facet Pfeufer, Arne
van Noord, Charlotte
Marciante, Kristin D.
Arking, Dan E.
Larson, Martin G.
Smith, Albert Vernon
Tarasov, Kirill V.
Müller, Martina
Sotoodehnia, Nona
Sinner, Moritz F.
Verwoert, Germaine C.
Li, Man
Kao, W.H. Linda
Köttgen, Anna
Coresh, Josef
Bis, Joshua C.
Psaty, Bruce M.
Rice, Kenneth
Rotter, Jerome I.
Rivadeneira, Fernando
Hofman, Albert
Kors, Jan A.
Stricker, Bruno H.C.
Uitterlinden, André G.
van Duijn, Cornelia M.
Beckmann, Britt M.
Sauter, Wiebke
Gieger, Christian
Lubitz, Steven A.
Newton-Cheh, Christopher
Wang, Thomas J.
Magnani, Jared W.
Schnabel, Renate B.
Chung, Mina K.
Barnard, John
Smith, Jonathan D.
Van Wagoner, David R.
Vasan, Ramachandran S.
Aspelund, Thor
Eiriksdottir, Gudny
Harris, Tamara B.
Launer, Lenore J.
Najjar, Samer S.
Lakatta, Edward
Schlessinger, David
Uda, Manuela
Abecasis, Gonçalo R.
Müller-Myhsok, Bertram
Ehret, Georg B.
Boerwinkle, Eric
Chakravarti, Aravinda
Soliman, Elsayed Z.
Lunetta, Kathryn L.
Perz, Siegfried
Wichmann, H.-Erich
Meitinger, Thomas
Levy, Daniel
Gudnason, Vilmundur
Ellinor, Patrick T.
Sanna, Serena
Kääb, Stefan
Witteman, Jacqueline C.M.
Alonso, Alvaro
Benjamin, Emelia J.
Heckbert, Susan R.
author_sort Pfeufer, Arne
collection PubMed
description The electrocardiographic PR interval reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation (AF). To identify underlying common genetic variation, we meta-analyzed genome-wide association results for PR interval from seven community-based studies of European-ancestry individuals in the CHARGE consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N=28,517). Statistically significant loci (P<5×10(-8)) were tested for association with AF (N=5,741 cases). We identified nine loci associated with PR interval. At chromosome 3p22.2, we observed two independent associations in voltage gated sodium channel genes SCN10A and SCN5A, while six loci were near cardiac developmental genes CAV1/CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5/TBX3. Another signal was at ARHGAP24, a locus without known relevance to the heart. Five of the nine loci, SCN5A, SCN10A, NKX2-5, CAV1/CAV2, and SOX5, were also associated with AF (P<0.0056). Common genetic variation, particularly in ion channel and developmental genes, contributes significantly to atrial and atrioventricular conduction and to AF risk.
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spelling pubmed-28501972010-08-01 Genome-wide association study of PR interval Pfeufer, Arne van Noord, Charlotte Marciante, Kristin D. Arking, Dan E. Larson, Martin G. Smith, Albert Vernon Tarasov, Kirill V. Müller, Martina Sotoodehnia, Nona Sinner, Moritz F. Verwoert, Germaine C. Li, Man Kao, W.H. Linda Köttgen, Anna Coresh, Josef Bis, Joshua C. Psaty, Bruce M. Rice, Kenneth Rotter, Jerome I. Rivadeneira, Fernando Hofman, Albert Kors, Jan A. Stricker, Bruno H.C. Uitterlinden, André G. van Duijn, Cornelia M. Beckmann, Britt M. Sauter, Wiebke Gieger, Christian Lubitz, Steven A. Newton-Cheh, Christopher Wang, Thomas J. Magnani, Jared W. Schnabel, Renate B. Chung, Mina K. Barnard, John Smith, Jonathan D. Van Wagoner, David R. Vasan, Ramachandran S. Aspelund, Thor Eiriksdottir, Gudny Harris, Tamara B. Launer, Lenore J. Najjar, Samer S. Lakatta, Edward Schlessinger, David Uda, Manuela Abecasis, Gonçalo R. Müller-Myhsok, Bertram Ehret, Georg B. Boerwinkle, Eric Chakravarti, Aravinda Soliman, Elsayed Z. Lunetta, Kathryn L. Perz, Siegfried Wichmann, H.-Erich Meitinger, Thomas Levy, Daniel Gudnason, Vilmundur Ellinor, Patrick T. Sanna, Serena Kääb, Stefan Witteman, Jacqueline C.M. Alonso, Alvaro Benjamin, Emelia J. Heckbert, Susan R. Nat Genet Article The electrocardiographic PR interval reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation (AF). To identify underlying common genetic variation, we meta-analyzed genome-wide association results for PR interval from seven community-based studies of European-ancestry individuals in the CHARGE consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N=28,517). Statistically significant loci (P<5×10(-8)) were tested for association with AF (N=5,741 cases). We identified nine loci associated with PR interval. At chromosome 3p22.2, we observed two independent associations in voltage gated sodium channel genes SCN10A and SCN5A, while six loci were near cardiac developmental genes CAV1/CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5/TBX3. Another signal was at ARHGAP24, a locus without known relevance to the heart. Five of the nine loci, SCN5A, SCN10A, NKX2-5, CAV1/CAV2, and SOX5, were also associated with AF (P<0.0056). Common genetic variation, particularly in ion channel and developmental genes, contributes significantly to atrial and atrioventricular conduction and to AF risk. 2010-01-10 2010-02 /pmc/articles/PMC2850197/ /pubmed/20062060 http://dx.doi.org/10.1038/ng.517 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Pfeufer, Arne
van Noord, Charlotte
Marciante, Kristin D.
Arking, Dan E.
Larson, Martin G.
Smith, Albert Vernon
Tarasov, Kirill V.
Müller, Martina
Sotoodehnia, Nona
Sinner, Moritz F.
Verwoert, Germaine C.
Li, Man
Kao, W.H. Linda
Köttgen, Anna
Coresh, Josef
Bis, Joshua C.
Psaty, Bruce M.
Rice, Kenneth
Rotter, Jerome I.
Rivadeneira, Fernando
Hofman, Albert
Kors, Jan A.
Stricker, Bruno H.C.
Uitterlinden, André G.
van Duijn, Cornelia M.
Beckmann, Britt M.
Sauter, Wiebke
Gieger, Christian
Lubitz, Steven A.
Newton-Cheh, Christopher
Wang, Thomas J.
Magnani, Jared W.
Schnabel, Renate B.
Chung, Mina K.
Barnard, John
Smith, Jonathan D.
Van Wagoner, David R.
Vasan, Ramachandran S.
Aspelund, Thor
Eiriksdottir, Gudny
Harris, Tamara B.
Launer, Lenore J.
Najjar, Samer S.
Lakatta, Edward
Schlessinger, David
Uda, Manuela
Abecasis, Gonçalo R.
Müller-Myhsok, Bertram
Ehret, Georg B.
Boerwinkle, Eric
Chakravarti, Aravinda
Soliman, Elsayed Z.
Lunetta, Kathryn L.
Perz, Siegfried
Wichmann, H.-Erich
Meitinger, Thomas
Levy, Daniel
Gudnason, Vilmundur
Ellinor, Patrick T.
Sanna, Serena
Kääb, Stefan
Witteman, Jacqueline C.M.
Alonso, Alvaro
Benjamin, Emelia J.
Heckbert, Susan R.
Genome-wide association study of PR interval
title Genome-wide association study of PR interval
title_full Genome-wide association study of PR interval
title_fullStr Genome-wide association study of PR interval
title_full_unstemmed Genome-wide association study of PR interval
title_short Genome-wide association study of PR interval
title_sort genome-wide association study of pr interval
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850197/
https://www.ncbi.nlm.nih.gov/pubmed/20062060
http://dx.doi.org/10.1038/ng.517
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