Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report

INTRODUCTION: Recent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways. CASE PRESENTATION: We present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammograph...

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Detalles Bibliográficos
Autores principales: Papantoniou, Vassilios J, Sotiropoulou, Evangelia K, Valsamaki, Pipitsa N, Tsaroucha, Angeliki G, Sotiropoulou, Maria G, Ptohis, Nikolaos D, Stipsanelli, Aikaterini J, Dimitrakakis, Konstantinos E, Marinopoulos, Spyridon G, Tsiouris, Spyridon T, Antsaklis, Aris J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Case report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850350/
https://www.ncbi.nlm.nih.gov/pubmed/20236511
http://dx.doi.org/10.1186/1752-1947-4-89
Descripción
Sumario:INTRODUCTION: Recent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways. CASE PRESENTATION: We present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammography by the proliferation-imaging tracer Technetium-99m-labelled pentavalent dimercaptosuccinic acid, before and after an oral ibuprofen treatment for 4 weeks. The radiotracer uptake after ibuprofen intake was significantly reduced, both visually and by semi-quantitative analysis, based on a calculation of lesion-to-background ratios. CONCLUSION: In proliferating breast lesions, scintigraphically displayed reduction in Technetium-99m-labelled pentavalent dimercaptosuccinic acid uptake may indicate inhibition by ibuprofen in the pathway of malignant epithelial cell transformation.

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