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Macrophages Recognize Size and Shape of Their Targets
Recognition by macrophages is a key process in generating immune response against invading pathogens. Previous studies have focused on recognition of pathogens through surface receptors present on the macrophage's surface. Here, using polymeric particles of different geometries that represent t...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850372/ https://www.ncbi.nlm.nih.gov/pubmed/20386614 http://dx.doi.org/10.1371/journal.pone.0010051 |
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author | Doshi, Nishit Mitragotri, Samir |
author_facet | Doshi, Nishit Mitragotri, Samir |
author_sort | Doshi, Nishit |
collection | PubMed |
description | Recognition by macrophages is a key process in generating immune response against invading pathogens. Previous studies have focused on recognition of pathogens through surface receptors present on the macrophage's surface. Here, using polymeric particles of different geometries that represent the size and shape range of a variety of bacteria, the importance of target geometry in recognition was investigated. The studies reported here reveal that attachment of particles of different geometries to macrophages exhibits a strong dependence on size and shape. For all sizes and shapes studied, particles possessing the longest dimension in the range of 2–3 µm exhibited highest attachment. This also happens to be the size range of most commonly found bacteria in nature. The surface features of macrophages, in particular the membrane ruffles, might play an important role in this geometry-based target recognition by macrophages. These findings have significant implications in understanding the pathogenicity of bacteria and in designing drug delivery carriers. |
format | Text |
id | pubmed-2850372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-28503722010-04-12 Macrophages Recognize Size and Shape of Their Targets Doshi, Nishit Mitragotri, Samir PLoS One Research Article Recognition by macrophages is a key process in generating immune response against invading pathogens. Previous studies have focused on recognition of pathogens through surface receptors present on the macrophage's surface. Here, using polymeric particles of different geometries that represent the size and shape range of a variety of bacteria, the importance of target geometry in recognition was investigated. The studies reported here reveal that attachment of particles of different geometries to macrophages exhibits a strong dependence on size and shape. For all sizes and shapes studied, particles possessing the longest dimension in the range of 2–3 µm exhibited highest attachment. This also happens to be the size range of most commonly found bacteria in nature. The surface features of macrophages, in particular the membrane ruffles, might play an important role in this geometry-based target recognition by macrophages. These findings have significant implications in understanding the pathogenicity of bacteria and in designing drug delivery carriers. Public Library of Science 2010-04-06 /pmc/articles/PMC2850372/ /pubmed/20386614 http://dx.doi.org/10.1371/journal.pone.0010051 Text en Doshi, Mitragotri. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Doshi, Nishit Mitragotri, Samir Macrophages Recognize Size and Shape of Their Targets |
title | Macrophages Recognize Size and Shape of Their Targets |
title_full | Macrophages Recognize Size and Shape of Their Targets |
title_fullStr | Macrophages Recognize Size and Shape of Their Targets |
title_full_unstemmed | Macrophages Recognize Size and Shape of Their Targets |
title_short | Macrophages Recognize Size and Shape of Their Targets |
title_sort | macrophages recognize size and shape of their targets |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850372/ https://www.ncbi.nlm.nih.gov/pubmed/20386614 http://dx.doi.org/10.1371/journal.pone.0010051 |
work_keys_str_mv | AT doshinishit macrophagesrecognizesizeandshapeoftheirtargets AT mitragotrisamir macrophagesrecognizesizeandshapeoftheirtargets |