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Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms

Realization of the exciting potential for stem-cell-based biomedical and therapeutic applications, including tissue engineering, requires an understanding of the cell-cell and cell-environment interactions. To this end, recent efforts have been focused on the manipulation of adult stem cell differen...

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Detalles Bibliográficos
Autores principales: Titushkin, Igor, Sun, Shan, Shin, Jennifer, Cho, Michael
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850549/
https://www.ncbi.nlm.nih.gov/pubmed/20379388
http://dx.doi.org/10.1155/2010/743476
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author Titushkin, Igor
Sun, Shan
Shin, Jennifer
Cho, Michael
author_facet Titushkin, Igor
Sun, Shan
Shin, Jennifer
Cho, Michael
author_sort Titushkin, Igor
collection PubMed
description Realization of the exciting potential for stem-cell-based biomedical and therapeutic applications, including tissue engineering, requires an understanding of the cell-cell and cell-environment interactions. To this end, recent efforts have been focused on the manipulation of adult stem cell differentiation using inductive soluble factors, designing suitable mechanical environments, and applying noninvasive physical forces. Although each of these different approaches has been successfully applied to regulate stem cell differentiation, it would be of great interest and importance to integrate and optimally combine a few or all of the physicochemical differentiation cues to induce synergistic stem cell differentiation. Furthermore, elucidation of molecular mechanisms that mediate the effects of multiple differentiation cues will enable the researcher to better manipulate stem cell behavior and response.
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spelling pubmed-28505492010-04-08 Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms Titushkin, Igor Sun, Shan Shin, Jennifer Cho, Michael J Biomed Biotechnol Review Article Realization of the exciting potential for stem-cell-based biomedical and therapeutic applications, including tissue engineering, requires an understanding of the cell-cell and cell-environment interactions. To this end, recent efforts have been focused on the manipulation of adult stem cell differentiation using inductive soluble factors, designing suitable mechanical environments, and applying noninvasive physical forces. Although each of these different approaches has been successfully applied to regulate stem cell differentiation, it would be of great interest and importance to integrate and optimally combine a few or all of the physicochemical differentiation cues to induce synergistic stem cell differentiation. Furthermore, elucidation of molecular mechanisms that mediate the effects of multiple differentiation cues will enable the researcher to better manipulate stem cell behavior and response. Hindawi Publishing Corporation 2010 2010-04-01 /pmc/articles/PMC2850549/ /pubmed/20379388 http://dx.doi.org/10.1155/2010/743476 Text en Copyright © 2010 Igor Titushkin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Titushkin, Igor
Sun, Shan
Shin, Jennifer
Cho, Michael
Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms
title Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms
title_full Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms
title_fullStr Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms
title_full_unstemmed Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms
title_short Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms
title_sort physicochemical control of adult stem cell differentiation: shedding light on potential molecular mechanisms
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850549/
https://www.ncbi.nlm.nih.gov/pubmed/20379388
http://dx.doi.org/10.1155/2010/743476
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