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Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms
Realization of the exciting potential for stem-cell-based biomedical and therapeutic applications, including tissue engineering, requires an understanding of the cell-cell and cell-environment interactions. To this end, recent efforts have been focused on the manipulation of adult stem cell differen...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850549/ https://www.ncbi.nlm.nih.gov/pubmed/20379388 http://dx.doi.org/10.1155/2010/743476 |
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author | Titushkin, Igor Sun, Shan Shin, Jennifer Cho, Michael |
author_facet | Titushkin, Igor Sun, Shan Shin, Jennifer Cho, Michael |
author_sort | Titushkin, Igor |
collection | PubMed |
description | Realization of the exciting potential for stem-cell-based biomedical and therapeutic applications, including tissue engineering, requires an understanding of the cell-cell and cell-environment interactions. To this end, recent efforts have been focused on the manipulation of adult stem cell differentiation using inductive soluble factors, designing suitable mechanical environments, and applying noninvasive physical forces. Although each of these different approaches has been successfully applied to regulate stem cell differentiation, it would be of great interest and importance to integrate and optimally combine a few or all of the physicochemical differentiation cues to induce synergistic stem cell differentiation. Furthermore, elucidation of molecular mechanisms that mediate the effects of multiple differentiation cues will enable the researcher to better manipulate stem cell behavior and response. |
format | Text |
id | pubmed-2850549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28505492010-04-08 Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms Titushkin, Igor Sun, Shan Shin, Jennifer Cho, Michael J Biomed Biotechnol Review Article Realization of the exciting potential for stem-cell-based biomedical and therapeutic applications, including tissue engineering, requires an understanding of the cell-cell and cell-environment interactions. To this end, recent efforts have been focused on the manipulation of adult stem cell differentiation using inductive soluble factors, designing suitable mechanical environments, and applying noninvasive physical forces. Although each of these different approaches has been successfully applied to regulate stem cell differentiation, it would be of great interest and importance to integrate and optimally combine a few or all of the physicochemical differentiation cues to induce synergistic stem cell differentiation. Furthermore, elucidation of molecular mechanisms that mediate the effects of multiple differentiation cues will enable the researcher to better manipulate stem cell behavior and response. Hindawi Publishing Corporation 2010 2010-04-01 /pmc/articles/PMC2850549/ /pubmed/20379388 http://dx.doi.org/10.1155/2010/743476 Text en Copyright © 2010 Igor Titushkin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Titushkin, Igor Sun, Shan Shin, Jennifer Cho, Michael Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms |
title | Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms |
title_full | Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms |
title_fullStr | Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms |
title_full_unstemmed | Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms |
title_short | Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms |
title_sort | physicochemical control of adult stem cell differentiation: shedding light on potential molecular mechanisms |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850549/ https://www.ncbi.nlm.nih.gov/pubmed/20379388 http://dx.doi.org/10.1155/2010/743476 |
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