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Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells
The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Thus, DCs-based vaccination represe...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850552/ https://www.ncbi.nlm.nih.gov/pubmed/20379390 http://dx.doi.org/10.1155/2010/752381 |
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author | Koido, Shigeo Homma, Sadamu Hara, Eiichi Namiki, Yoshihisa Ohkusa, Toshifumi Gong, Jianlin Tajiri, Hisao |
author_facet | Koido, Shigeo Homma, Sadamu Hara, Eiichi Namiki, Yoshihisa Ohkusa, Toshifumi Gong, Jianlin Tajiri, Hisao |
author_sort | Koido, Shigeo |
collection | PubMed |
description | The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Thus, DCs-based vaccination represents a potentially powerful strategy for induction of antigen-specific CTLs. Fusions of DCs and whole tumor cells represent an alternative approach to deliver, process, and subsequently present a broad spectrum of antigens, including those known and unidentified, in the context of costimulatory molecules. Once DCs/tumor fusions have been infused back into patient, they migrate to secondary lymphoid organs, where the generation of antigen-specific polyclonal CTL responses occurs. We will discuss perspectives for future development of DCs/tumor fusions for CTL induction. |
format | Text |
id | pubmed-2850552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28505522010-04-08 Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells Koido, Shigeo Homma, Sadamu Hara, Eiichi Namiki, Yoshihisa Ohkusa, Toshifumi Gong, Jianlin Tajiri, Hisao J Biomed Biotechnol Review Article The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Thus, DCs-based vaccination represents a potentially powerful strategy for induction of antigen-specific CTLs. Fusions of DCs and whole tumor cells represent an alternative approach to deliver, process, and subsequently present a broad spectrum of antigens, including those known and unidentified, in the context of costimulatory molecules. Once DCs/tumor fusions have been infused back into patient, they migrate to secondary lymphoid organs, where the generation of antigen-specific polyclonal CTL responses occurs. We will discuss perspectives for future development of DCs/tumor fusions for CTL induction. Hindawi Publishing Corporation 2010 2010-04-07 /pmc/articles/PMC2850552/ /pubmed/20379390 http://dx.doi.org/10.1155/2010/752381 Text en Copyright © 2010 Shigeo Koido et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Koido, Shigeo Homma, Sadamu Hara, Eiichi Namiki, Yoshihisa Ohkusa, Toshifumi Gong, Jianlin Tajiri, Hisao Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells |
title | Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells |
title_full | Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells |
title_fullStr | Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells |
title_full_unstemmed | Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells |
title_short | Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells |
title_sort | antigen-specific polyclonal cytotoxic t lymphocytes induced by fusions of dendritic cells and tumor cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850552/ https://www.ncbi.nlm.nih.gov/pubmed/20379390 http://dx.doi.org/10.1155/2010/752381 |
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