Cargando…

Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells

The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Thus, DCs-based vaccination represe...

Descripción completa

Detalles Bibliográficos
Autores principales: Koido, Shigeo, Homma, Sadamu, Hara, Eiichi, Namiki, Yoshihisa, Ohkusa, Toshifumi, Gong, Jianlin, Tajiri, Hisao
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850552/
https://www.ncbi.nlm.nih.gov/pubmed/20379390
http://dx.doi.org/10.1155/2010/752381
_version_ 1782179794029379584
author Koido, Shigeo
Homma, Sadamu
Hara, Eiichi
Namiki, Yoshihisa
Ohkusa, Toshifumi
Gong, Jianlin
Tajiri, Hisao
author_facet Koido, Shigeo
Homma, Sadamu
Hara, Eiichi
Namiki, Yoshihisa
Ohkusa, Toshifumi
Gong, Jianlin
Tajiri, Hisao
author_sort Koido, Shigeo
collection PubMed
description The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Thus, DCs-based vaccination represents a potentially powerful strategy for induction of antigen-specific CTLs. Fusions of DCs and whole tumor cells represent an alternative approach to deliver, process, and subsequently present a broad spectrum of antigens, including those known and unidentified, in the context of costimulatory molecules. Once DCs/tumor fusions have been infused back into patient, they migrate to secondary lymphoid organs, where the generation of antigen-specific polyclonal CTL responses occurs. We will discuss perspectives for future development of DCs/tumor fusions for CTL induction.
format Text
id pubmed-2850552
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-28505522010-04-08 Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells Koido, Shigeo Homma, Sadamu Hara, Eiichi Namiki, Yoshihisa Ohkusa, Toshifumi Gong, Jianlin Tajiri, Hisao J Biomed Biotechnol Review Article The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Thus, DCs-based vaccination represents a potentially powerful strategy for induction of antigen-specific CTLs. Fusions of DCs and whole tumor cells represent an alternative approach to deliver, process, and subsequently present a broad spectrum of antigens, including those known and unidentified, in the context of costimulatory molecules. Once DCs/tumor fusions have been infused back into patient, they migrate to secondary lymphoid organs, where the generation of antigen-specific polyclonal CTL responses occurs. We will discuss perspectives for future development of DCs/tumor fusions for CTL induction. Hindawi Publishing Corporation 2010 2010-04-07 /pmc/articles/PMC2850552/ /pubmed/20379390 http://dx.doi.org/10.1155/2010/752381 Text en Copyright © 2010 Shigeo Koido et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Koido, Shigeo
Homma, Sadamu
Hara, Eiichi
Namiki, Yoshihisa
Ohkusa, Toshifumi
Gong, Jianlin
Tajiri, Hisao
Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells
title Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells
title_full Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells
title_fullStr Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells
title_full_unstemmed Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells
title_short Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells
title_sort antigen-specific polyclonal cytotoxic t lymphocytes induced by fusions of dendritic cells and tumor cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850552/
https://www.ncbi.nlm.nih.gov/pubmed/20379390
http://dx.doi.org/10.1155/2010/752381
work_keys_str_mv AT koidoshigeo antigenspecificpolyclonalcytotoxictlymphocytesinducedbyfusionsofdendriticcellsandtumorcells
AT hommasadamu antigenspecificpolyclonalcytotoxictlymphocytesinducedbyfusionsofdendriticcellsandtumorcells
AT haraeiichi antigenspecificpolyclonalcytotoxictlymphocytesinducedbyfusionsofdendriticcellsandtumorcells
AT namikiyoshihisa antigenspecificpolyclonalcytotoxictlymphocytesinducedbyfusionsofdendriticcellsandtumorcells
AT ohkusatoshifumi antigenspecificpolyclonalcytotoxictlymphocytesinducedbyfusionsofdendriticcellsandtumorcells
AT gongjianlin antigenspecificpolyclonalcytotoxictlymphocytesinducedbyfusionsofdendriticcellsandtumorcells
AT tajirihisao antigenspecificpolyclonalcytotoxictlymphocytesinducedbyfusionsofdendriticcellsandtumorcells