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The Quality of Life of Adult Survivors of Childhood Hematopoietic Cell Transplant

Survival rates following myeloablative hematopoietic cell transplantation (HCT) in childhood have improved. We conducted a cross-sectional study evaluating the quality of life (QOL) of 214 adult survivors of a childhood HCT compared to controls using standardized self report measures with strong psy...

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Detalles Bibliográficos
Autores principales: Sanders, Jean E., Hoffmeister, Paul A., Storer, Barry E., Appelbaum, Frederick R., Storb, Rainer F., Syrjala, Karen L.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850957/
https://www.ncbi.nlm.nih.gov/pubmed/19718073
http://dx.doi.org/10.1038/bmt.2009.224
Descripción
Sumario:Survival rates following myeloablative hematopoietic cell transplantation (HCT) in childhood have improved. We conducted a cross-sectional study evaluating the quality of life (QOL) of 214 adult survivors of a childhood HCT compared to controls using standardized self report measures with strong psychometric properties to evaluate physical function, psychological function, and cognitive symptoms. From these results we conducted a multivariate analysis of risk factors. This analysis for physical functioning showed poorer function among myeloid disease survivors compared to patients with all other diagnoses (p=0.02), males functioned better than females (p=0.05) and those >18 years after transplant functioned more poorly than those <18 years after transplant (p=0.05). Psychological functioning showed those who received more therapy and females were more likely to be depressed (p=0.03) and (p=0.005). Perceived cognitive symptoms demonstrated that female survivors had more symptoms than male survivors (p=0.01), and those receiving more preceding therapy compared to those with less preceding therapy (p=0.001) or cranial irradiation compared to those without cranial irradiation (p=0.002) had more perceived cognitive symptoms. Overall, these data indicate the majority of adult survivors of a childhood transplant are functioning well, but some have problems which need to be addressed.