The Neurobiology of Opioid Dependence: Implications for Treatment

Opioid tolerance, dependence, and addiction are all manifestations of brain changes resulting from chronic opioid abuse. The opioid abuser’s struggle for recovery is in great part a struggle to overcome the effects of these changes. Medications such as methadone, LAAM, buprenorphine, and naltrexone...

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Detalles Bibliográficos
Autores principales: Kosten, Thomas R., George, Tony P.
Formato: Texto
Lenguaje:English
Publicado: National Institute on Drug Abuse 2002
Materias:
Research Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851054/
https://www.ncbi.nlm.nih.gov/pubmed/18567959
Descripción
Sumario:Opioid tolerance, dependence, and addiction are all manifestations of brain changes resulting from chronic opioid abuse. The opioid abuser’s struggle for recovery is in great part a struggle to overcome the effects of these changes. Medications such as methadone, LAAM, buprenorphine, and naltrexone act on the same brain structures and processes as addictive opioids, but with protective or normalizing effects. Despite the effectiveness of medications, they must be used in conjunction with appropriate psychosocial treatments.

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