The Neurobiology of Opioid Dependence: Implications for Treatment

Opioid tolerance, dependence, and addiction are all manifestations of brain changes resulting from chronic opioid abuse. The opioid abuser’s struggle for recovery is in great part a struggle to overcome the effects of these changes. Medications such as methadone, LAAM, buprenorphine, and naltrexone...

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Detalles Bibliográficos
Autores principales: Kosten, Thomas R., George, Tony P.
Formato: Texto
Lenguaje:English
Publicado: National Institute on Drug Abuse 2002
Materias:
Research Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851054/
https://www.ncbi.nlm.nih.gov/pubmed/18567959
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author Kosten, Thomas R.
George, Tony P.
author_facet Kosten, Thomas R.
George, Tony P.
author_sort Kosten, Thomas R.
collection PubMed
description Opioid tolerance, dependence, and addiction are all manifestations of brain changes resulting from chronic opioid abuse. The opioid abuser’s struggle for recovery is in great part a struggle to overcome the effects of these changes. Medications such as methadone, LAAM, buprenorphine, and naltrexone act on the same brain structures and processes as addictive opioids, but with protective or normalizing effects. Despite the effectiveness of medications, they must be used in conjunction with appropriate psychosocial treatments.
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spelling pubmed-28510542010-10-25 The Neurobiology of Opioid Dependence: Implications for Treatment Kosten, Thomas R. George, Tony P. Sci Pract Perspect Research Review Opioid tolerance, dependence, and addiction are all manifestations of brain changes resulting from chronic opioid abuse. The opioid abuser’s struggle for recovery is in great part a struggle to overcome the effects of these changes. Medications such as methadone, LAAM, buprenorphine, and naltrexone act on the same brain structures and processes as addictive opioids, but with protective or normalizing effects. Despite the effectiveness of medications, they must be used in conjunction with appropriate psychosocial treatments. National Institute on Drug Abuse 2002-07 /pmc/articles/PMC2851054/ /pubmed/18567959 Text en
spellingShingle Research Review
Kosten, Thomas R.
George, Tony P.
The Neurobiology of Opioid Dependence: Implications for Treatment
title The Neurobiology of Opioid Dependence: Implications for Treatment
title_full The Neurobiology of Opioid Dependence: Implications for Treatment
title_fullStr The Neurobiology of Opioid Dependence: Implications for Treatment
title_full_unstemmed The Neurobiology of Opioid Dependence: Implications for Treatment
title_short The Neurobiology of Opioid Dependence: Implications for Treatment
title_sort neurobiology of opioid dependence: implications for treatment
topic Research Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851054/
https://www.ncbi.nlm.nih.gov/pubmed/18567959
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