Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor

BACKGROUND: Macrophages expressing the pro-angiogenic transcription factor hypoxia-inducible factor (HIF)-1alpha have been demonstrated in rheumatoid arthritis (RA) in the synovial tissue. Aim of the present study was to investigate intracellular signal transduction regulation of pro-inflammatory HI...

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Detalles Bibliográficos
Autores principales: Westra, Johanna, Brouwer, Elisabeth, van Roosmalen, Ingrid AM, Doornbos-van der Meer, Berber, van Leeuwen, Miek A, Posthumus, Marcel D, Kallenberg, Cees GM
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851671/
https://www.ncbi.nlm.nih.gov/pubmed/20353560
http://dx.doi.org/10.1186/1471-2474-11-61

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