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Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis
AIM: The aim of this study was to determine whether primary nocturnal enuresis (PNE) leads to alterations in glycosaminoglycan (GAG) excretion. METHODS: Twenty subjects (mean age 8.7 years, M/F 15/5) with PNE were included in the study. Twenty-two healthy subjects were selected as a control group (m...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851705/ https://www.ncbi.nlm.nih.gov/pubmed/20181082 http://dx.doi.org/10.1186/1824-7288-36-13 |
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author | Budak, Yasemin U Huysal, Kağan Guray, Atilla |
author_facet | Budak, Yasemin U Huysal, Kağan Guray, Atilla |
author_sort | Budak, Yasemin U |
collection | PubMed |
description | AIM: The aim of this study was to determine whether primary nocturnal enuresis (PNE) leads to alterations in glycosaminoglycan (GAG) excretion. METHODS: Twenty subjects (mean age 8.7 years, M/F 15/5) with PNE were included in the study. Twenty-two healthy subjects were selected as a control group (mean age 8.7 years, M/F 14/8). Urinary GAG excretion was measured using a modified dimethylmethylene blue (DMD) assay of 24-hour urine. RESULTS: The mean urinary GAG content was 33.9 mg/g and 23.8 mg/g creatinine in patients with PNE and controls, respectively; patients with PNE thus had a higher mean GAG excretion than did age-matched controls (p < 0.05). The association between GAG level and enuresis frequency bordered on significance (p = 0.068). CONCLUSIONS: GAG excretion in patients with PNE was significantly higher than in normal children, suggesting that measurement of urinary GAG may be useful in evaluating physiopathological conditions of the bladder wall. Further studies are needed to confirm this finding. |
format | Text |
id | pubmed-2851705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28517052010-04-09 Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis Budak, Yasemin U Huysal, Kağan Guray, Atilla Ital J Pediatr Research AIM: The aim of this study was to determine whether primary nocturnal enuresis (PNE) leads to alterations in glycosaminoglycan (GAG) excretion. METHODS: Twenty subjects (mean age 8.7 years, M/F 15/5) with PNE were included in the study. Twenty-two healthy subjects were selected as a control group (mean age 8.7 years, M/F 14/8). Urinary GAG excretion was measured using a modified dimethylmethylene blue (DMD) assay of 24-hour urine. RESULTS: The mean urinary GAG content was 33.9 mg/g and 23.8 mg/g creatinine in patients with PNE and controls, respectively; patients with PNE thus had a higher mean GAG excretion than did age-matched controls (p < 0.05). The association between GAG level and enuresis frequency bordered on significance (p = 0.068). CONCLUSIONS: GAG excretion in patients with PNE was significantly higher than in normal children, suggesting that measurement of urinary GAG may be useful in evaluating physiopathological conditions of the bladder wall. Further studies are needed to confirm this finding. BioMed Central 2010-02-03 /pmc/articles/PMC2851705/ /pubmed/20181082 http://dx.doi.org/10.1186/1824-7288-36-13 Text en Copyright ©2010 Budak et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Budak, Yasemin U Huysal, Kağan Guray, Atilla Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis |
title | Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis |
title_full | Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis |
title_fullStr | Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis |
title_full_unstemmed | Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis |
title_short | Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis |
title_sort | urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851705/ https://www.ncbi.nlm.nih.gov/pubmed/20181082 http://dx.doi.org/10.1186/1824-7288-36-13 |
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