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Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis

AIM: The aim of this study was to determine whether primary nocturnal enuresis (PNE) leads to alterations in glycosaminoglycan (GAG) excretion. METHODS: Twenty subjects (mean age 8.7 years, M/F 15/5) with PNE were included in the study. Twenty-two healthy subjects were selected as a control group (m...

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Autores principales: Budak, Yasemin U, Huysal, Kağan, Guray, Atilla
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851705/
https://www.ncbi.nlm.nih.gov/pubmed/20181082
http://dx.doi.org/10.1186/1824-7288-36-13
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author Budak, Yasemin U
Huysal, Kağan
Guray, Atilla
author_facet Budak, Yasemin U
Huysal, Kağan
Guray, Atilla
author_sort Budak, Yasemin U
collection PubMed
description AIM: The aim of this study was to determine whether primary nocturnal enuresis (PNE) leads to alterations in glycosaminoglycan (GAG) excretion. METHODS: Twenty subjects (mean age 8.7 years, M/F 15/5) with PNE were included in the study. Twenty-two healthy subjects were selected as a control group (mean age 8.7 years, M/F 14/8). Urinary GAG excretion was measured using a modified dimethylmethylene blue (DMD) assay of 24-hour urine. RESULTS: The mean urinary GAG content was 33.9 mg/g and 23.8 mg/g creatinine in patients with PNE and controls, respectively; patients with PNE thus had a higher mean GAG excretion than did age-matched controls (p < 0.05). The association between GAG level and enuresis frequency bordered on significance (p = 0.068). CONCLUSIONS: GAG excretion in patients with PNE was significantly higher than in normal children, suggesting that measurement of urinary GAG may be useful in evaluating physiopathological conditions of the bladder wall. Further studies are needed to confirm this finding.
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spelling pubmed-28517052010-04-09 Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis Budak, Yasemin U Huysal, Kağan Guray, Atilla Ital J Pediatr Research AIM: The aim of this study was to determine whether primary nocturnal enuresis (PNE) leads to alterations in glycosaminoglycan (GAG) excretion. METHODS: Twenty subjects (mean age 8.7 years, M/F 15/5) with PNE were included in the study. Twenty-two healthy subjects were selected as a control group (mean age 8.7 years, M/F 14/8). Urinary GAG excretion was measured using a modified dimethylmethylene blue (DMD) assay of 24-hour urine. RESULTS: The mean urinary GAG content was 33.9 mg/g and 23.8 mg/g creatinine in patients with PNE and controls, respectively; patients with PNE thus had a higher mean GAG excretion than did age-matched controls (p < 0.05). The association between GAG level and enuresis frequency bordered on significance (p = 0.068). CONCLUSIONS: GAG excretion in patients with PNE was significantly higher than in normal children, suggesting that measurement of urinary GAG may be useful in evaluating physiopathological conditions of the bladder wall. Further studies are needed to confirm this finding. BioMed Central 2010-02-03 /pmc/articles/PMC2851705/ /pubmed/20181082 http://dx.doi.org/10.1186/1824-7288-36-13 Text en Copyright ©2010 Budak et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Budak, Yasemin U
Huysal, Kağan
Guray, Atilla
Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis
title Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis
title_full Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis
title_fullStr Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis
title_full_unstemmed Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis
title_short Urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis
title_sort urinary glycosaminoglycan excretion in patients with primary nocturnal enuresis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851705/
https://www.ncbi.nlm.nih.gov/pubmed/20181082
http://dx.doi.org/10.1186/1824-7288-36-13
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