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Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life
BACKGROUND: evaluation of thyroid function in neonates born from mothers affected by autoimmune thyroiditis in order to define if a precise follow-up is necessary for these children. The influence of maternal thyroid peroxidase antibody (TPOAb) and L-thyroxine therapy during pregnancy on neonatal th...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851706/ https://www.ncbi.nlm.nih.gov/pubmed/20219125 http://dx.doi.org/10.1186/1824-7288-36-24 |
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author | Rovelli, Rosanna Vigone, Maria Cristina Giovanettoni, Chiara Passoni, Arianna Maina, Ludovica Corrias, Andrea Corbetta, Carlo Mosca, Fabio Chiumello, Giuseppe Weber, Giovanna |
author_facet | Rovelli, Rosanna Vigone, Maria Cristina Giovanettoni, Chiara Passoni, Arianna Maina, Ludovica Corrias, Andrea Corbetta, Carlo Mosca, Fabio Chiumello, Giuseppe Weber, Giovanna |
author_sort | Rovelli, Rosanna |
collection | PubMed |
description | BACKGROUND: evaluation of thyroid function in neonates born from mothers affected by autoimmune thyroiditis in order to define if a precise follow-up is necessary for these children. The influence of maternal thyroid peroxidase antibody (TPOAb) and L-thyroxine therapy during pregnancy on neonatal thyroid function was also investigated. METHODS: 129 neonates were tested for thyroid function by measurement of free thyroxine (FT4) and thyroid stimulating hormone (TSH) in 3(th )day, 15(th )day and at one month of life. TPOAb were measured in all patients; periodical control of thyroid function were performed until 6 months of life if Ab were positive. Data concerning etiology of maternal hypothyroidism and maternal replacement therapy with L-thyroxine during pregnancy were retrospectively collected. RESULTS: 28% neonates showed at least a mild increase of TSH value at the different determinations. In the majority of them, a spontaneous completely normalisation of TSH value was observed within the first month life. L-thyroxine replacement therapy was started in 3 neonates. TPOAb titer and maternal L-thyroxine replacement therapy were not related to alteration of thyroid hormone function in our study population. CONCLUSIONS: transient mild elevation of serum TSH above the normal reference value for age is frequently observed in the first month of life in infants born from mothers affected by autoimmune thyroiditis. Persistent hyperthyrotropinemia requiring replacement therapy is observed in 2.2% of these neonates. According to our experience, follow-up is recommended in these newborns; the most accurate and not invasive way to carefully monitor these infants after neonatal screening for CH seems to be serum-testing TSH between 2(nd)and 4(th )week of life. |
format | Text |
id | pubmed-2851706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28517062010-04-09 Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life Rovelli, Rosanna Vigone, Maria Cristina Giovanettoni, Chiara Passoni, Arianna Maina, Ludovica Corrias, Andrea Corbetta, Carlo Mosca, Fabio Chiumello, Giuseppe Weber, Giovanna Ital J Pediatr Research BACKGROUND: evaluation of thyroid function in neonates born from mothers affected by autoimmune thyroiditis in order to define if a precise follow-up is necessary for these children. The influence of maternal thyroid peroxidase antibody (TPOAb) and L-thyroxine therapy during pregnancy on neonatal thyroid function was also investigated. METHODS: 129 neonates were tested for thyroid function by measurement of free thyroxine (FT4) and thyroid stimulating hormone (TSH) in 3(th )day, 15(th )day and at one month of life. TPOAb were measured in all patients; periodical control of thyroid function were performed until 6 months of life if Ab were positive. Data concerning etiology of maternal hypothyroidism and maternal replacement therapy with L-thyroxine during pregnancy were retrospectively collected. RESULTS: 28% neonates showed at least a mild increase of TSH value at the different determinations. In the majority of them, a spontaneous completely normalisation of TSH value was observed within the first month life. L-thyroxine replacement therapy was started in 3 neonates. TPOAb titer and maternal L-thyroxine replacement therapy were not related to alteration of thyroid hormone function in our study population. CONCLUSIONS: transient mild elevation of serum TSH above the normal reference value for age is frequently observed in the first month of life in infants born from mothers affected by autoimmune thyroiditis. Persistent hyperthyrotropinemia requiring replacement therapy is observed in 2.2% of these neonates. According to our experience, follow-up is recommended in these newborns; the most accurate and not invasive way to carefully monitor these infants after neonatal screening for CH seems to be serum-testing TSH between 2(nd)and 4(th )week of life. BioMed Central 2010-03-10 /pmc/articles/PMC2851706/ /pubmed/20219125 http://dx.doi.org/10.1186/1824-7288-36-24 Text en Copyright ©2010 Rovelli et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Rovelli, Rosanna Vigone, Maria Cristina Giovanettoni, Chiara Passoni, Arianna Maina, Ludovica Corrias, Andrea Corbetta, Carlo Mosca, Fabio Chiumello, Giuseppe Weber, Giovanna Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life |
title | Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life |
title_full | Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life |
title_fullStr | Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life |
title_full_unstemmed | Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life |
title_short | Newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life |
title_sort | newborn of mothers affected by autoimmune thyroiditis: the importance of thyroid function monitoring in the first months of life |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851706/ https://www.ncbi.nlm.nih.gov/pubmed/20219125 http://dx.doi.org/10.1186/1824-7288-36-24 |
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