Novel 2-Pyrazoline Derivatives as Potential Antibacterial and Antifungal Agents

The 1,3,5-trisubstituted-2-pyrazolines were synthesized by refluxing isoniazid with various substituted diarylchalcones in N,N-dimethylformamide at 120-140°. The physical and spectral data such as M.P., R(f), elemental analysis, IR, NMR and Mass was obtained for the synthesized compounds and the str...

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Detalles Bibliográficos
Autores principales: Kini, Suvarna, Gandhi, A. M.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852045/
https://www.ncbi.nlm.nih.gov/pubmed/20390093
http://dx.doi.org/10.4103/0250-474X.40344
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author Kini, Suvarna
Gandhi, A. M.
author_facet Kini, Suvarna
Gandhi, A. M.
author_sort Kini, Suvarna
collection PubMed
description The 1,3,5-trisubstituted-2-pyrazolines were synthesized by refluxing isoniazid with various substituted diarylchalcones in N,N-dimethylformamide at 120-140°. The physical and spectral data such as M.P., R(f), elemental analysis, IR, NMR and Mass was obtained for the synthesized compounds and the structures were confirmed. The screening of the synthesized compounds for antimicrobial activity was performed against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Aspergillus niger.
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spelling pubmed-28520452010-04-13 Novel 2-Pyrazoline Derivatives as Potential Antibacterial and Antifungal Agents Kini, Suvarna Gandhi, A. M. Indian J Pharm Sci Short Communication The 1,3,5-trisubstituted-2-pyrazolines were synthesized by refluxing isoniazid with various substituted diarylchalcones in N,N-dimethylformamide at 120-140°. The physical and spectral data such as M.P., R(f), elemental analysis, IR, NMR and Mass was obtained for the synthesized compounds and the structures were confirmed. The screening of the synthesized compounds for antimicrobial activity was performed against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Aspergillus niger. Medknow Publications 2008 /pmc/articles/PMC2852045/ /pubmed/20390093 http://dx.doi.org/10.4103/0250-474X.40344 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Kini, Suvarna
Gandhi, A. M.
Novel 2-Pyrazoline Derivatives as Potential Antibacterial and Antifungal Agents
title Novel 2-Pyrazoline Derivatives as Potential Antibacterial and Antifungal Agents
title_full Novel 2-Pyrazoline Derivatives as Potential Antibacterial and Antifungal Agents
title_fullStr Novel 2-Pyrazoline Derivatives as Potential Antibacterial and Antifungal Agents
title_full_unstemmed Novel 2-Pyrazoline Derivatives as Potential Antibacterial and Antifungal Agents
title_short Novel 2-Pyrazoline Derivatives as Potential Antibacterial and Antifungal Agents
title_sort novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852045/
https://www.ncbi.nlm.nih.gov/pubmed/20390093
http://dx.doi.org/10.4103/0250-474X.40344
work_keys_str_mv AT kinisuvarna novel2pyrazolinederivativesaspotentialantibacterialandantifungalagents
AT gandhiam novel2pyrazolinederivativesaspotentialantibacterialandantifungalagents

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