Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates

A series of the title compounds were synthesized and characterized by spectral data. All the compounds were evaluated for in vitro antihistaminic activity by inhibition of isotonic contractions induced by histamine on isolated guinea pig ileum and the compound 6-k showed significant activity. A few...

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Detalles Bibliográficos
Autores principales: Gajbhiye, Asmita, Mallareddy, V., Achaiah, G.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852050/
https://www.ncbi.nlm.nih.gov/pubmed/20390097
http://dx.doi.org/10.4103/0250-474X.40348
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author Gajbhiye, Asmita
Mallareddy, V.
Achaiah, G.
author_facet Gajbhiye, Asmita
Mallareddy, V.
Achaiah, G.
author_sort Gajbhiye, Asmita
collection PubMed
description A series of the title compounds were synthesized and characterized by spectral data. All the compounds were evaluated for in vitro antihistaminic activity by inhibition of isotonic contractions induced by histamine on isolated guinea pig ileum and the compound 6-k showed significant activity. A few compounds have also been screened for in vivo bronchodilatory activity. These compounds exhibited significant protection against histamine-induced convulsions in guinea pig at the dose of 50 μmol.
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spelling pubmed-28520502010-04-13 Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates Gajbhiye, Asmita Mallareddy, V. Achaiah, G. Indian J Pharm Sci Short Communication A series of the title compounds were synthesized and characterized by spectral data. All the compounds were evaluated for in vitro antihistaminic activity by inhibition of isotonic contractions induced by histamine on isolated guinea pig ileum and the compound 6-k showed significant activity. A few compounds have also been screened for in vivo bronchodilatory activity. These compounds exhibited significant protection against histamine-induced convulsions in guinea pig at the dose of 50 μmol. Medknow Publications 2008 /pmc/articles/PMC2852050/ /pubmed/20390097 http://dx.doi.org/10.4103/0250-474X.40348 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Gajbhiye, Asmita
Mallareddy, V.
Achaiah, G.
Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates
title Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates
title_full Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates
title_fullStr Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates
title_full_unstemmed Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates
title_short Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates
title_sort synthesis and pharmacological evaluation of (6-substituted 4-oxo-4h-chromene-3 yl) methyl n-substituted aminoacetates
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852050/
https://www.ncbi.nlm.nih.gov/pubmed/20390097
http://dx.doi.org/10.4103/0250-474X.40348
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AT mallareddyv synthesisandpharmacologicalevaluationof6substituted4oxo4hchromene3ylmethylnsubstitutedaminoacetates
AT achaiahg synthesisandpharmacologicalevaluationof6substituted4oxo4hchromene3ylmethylnsubstitutedaminoacetates

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