Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method

A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, λ max of esomeprazole and domper...

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Autores principales: Prabu, S. Lakshmana, Shirwaikar, A., Shirwaikar, Annie, Kumar, C. Dinesh, Joseph, A., Kumar, R.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852053/
https://www.ncbi.nlm.nih.gov/pubmed/20390100
http://dx.doi.org/10.4103/0250-474X.40351
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author Prabu, S. Lakshmana
Shirwaikar, A.
Shirwaikar, Annie
Kumar, C. Dinesh
Joseph, A.
Kumar, R.
author_facet Prabu, S. Lakshmana
Shirwaikar, A.
Shirwaikar, Annie
Kumar, C. Dinesh
Joseph, A.
Kumar, R.
author_sort Prabu, S. Lakshmana
collection PubMed
description A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, λ max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 μg/ml and 8-30 μg/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form.
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spelling pubmed-28520532010-04-13 Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method Prabu, S. Lakshmana Shirwaikar, A. Shirwaikar, Annie Kumar, C. Dinesh Joseph, A. Kumar, R. Indian J Pharm Sci Short Communication A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, λ max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 μg/ml and 8-30 μg/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form. Medknow Publications 2008 /pmc/articles/PMC2852053/ /pubmed/20390100 http://dx.doi.org/10.4103/0250-474X.40351 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Prabu, S. Lakshmana
Shirwaikar, A.
Shirwaikar, Annie
Kumar, C. Dinesh
Joseph, A.
Kumar, R.
Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method
title Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method
title_full Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method
title_fullStr Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method
title_full_unstemmed Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method
title_short Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method
title_sort simultaneous estimation of esomeprazole and domperidone by uv spectrophotometric method
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852053/
https://www.ncbi.nlm.nih.gov/pubmed/20390100
http://dx.doi.org/10.4103/0250-474X.40351
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