Cargando…
Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide
Mucoadhesive buccal films of glipizide were prepared by solvent casting technique using hydroxypropylmethylcellulose, sodium carboxymethylcellulose, carbopol-934P and Eudragit RL-100. Prepared films were evaluated for weight, thickness, surface pH, swelling index, in vitro residence time, folding en...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852059/ https://www.ncbi.nlm.nih.gov/pubmed/20390079 http://dx.doi.org/10.4103/0250-474X.40330 |
_version_ | 1782179913893150720 |
---|---|
author | Semalty, Mona Semalty, A. Kumar, G. |
author_facet | Semalty, Mona Semalty, A. Kumar, G. |
author_sort | Semalty, Mona |
collection | PubMed |
description | Mucoadhesive buccal films of glipizide were prepared by solvent casting technique using hydroxypropylmethylcellulose, sodium carboxymethylcellulose, carbopol-934P and Eudragit RL-100. Prepared films were evaluated for weight, thickness, surface pH, swelling index, in vitro residence time, folding endurance, in vitro release, permeation studies and drug content uniformity. The films exhibited controlled release over more than 6 h. From the study it was concluded that the films containing 5 mg glipizide in 4.9% w/v hydroxypropylmethylcellulose and 1.5% w/v sodium carboxymethylcellulose exhibited satisfactory swelling, an optimum residence time and promising drug release. The formulation was found to be suitable candidate for the development of buccal films for therapeutic use. |
format | Text |
id | pubmed-2852059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28520592010-04-13 Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide Semalty, Mona Semalty, A. Kumar, G. Indian J Pharm Sci Research Paper Mucoadhesive buccal films of glipizide were prepared by solvent casting technique using hydroxypropylmethylcellulose, sodium carboxymethylcellulose, carbopol-934P and Eudragit RL-100. Prepared films were evaluated for weight, thickness, surface pH, swelling index, in vitro residence time, folding endurance, in vitro release, permeation studies and drug content uniformity. The films exhibited controlled release over more than 6 h. From the study it was concluded that the films containing 5 mg glipizide in 4.9% w/v hydroxypropylmethylcellulose and 1.5% w/v sodium carboxymethylcellulose exhibited satisfactory swelling, an optimum residence time and promising drug release. The formulation was found to be suitable candidate for the development of buccal films for therapeutic use. Medknow Publications 2008 /pmc/articles/PMC2852059/ /pubmed/20390079 http://dx.doi.org/10.4103/0250-474X.40330 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Semalty, Mona Semalty, A. Kumar, G. Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide |
title | Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide |
title_full | Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide |
title_fullStr | Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide |
title_full_unstemmed | Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide |
title_short | Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide |
title_sort | formulation and characterization of mucoadhesive buccal films of glipizide |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852059/ https://www.ncbi.nlm.nih.gov/pubmed/20390079 http://dx.doi.org/10.4103/0250-474X.40330 |
work_keys_str_mv | AT semaltymona formulationandcharacterizationofmucoadhesivebuccalfilmsofglipizide AT semaltya formulationandcharacterizationofmucoadhesivebuccalfilmsofglipizide AT kumarg formulationandcharacterizationofmucoadhesivebuccalfilmsofglipizide |