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Optimization of Fast Dissolving Etoricoxib Tablets Prepared by Sublimation Technique
The purpose of this investigation was to develop fast dissolving tablets of etoricoxib. Granules containing etoricoxib, menthol, crospovidone, aspartame and mannitol were prepared by wet granulation technique. Menthol was sublimed from the granules by exposing the granules to vacuum. The porous gran...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852065/ https://www.ncbi.nlm.nih.gov/pubmed/20390084 http://dx.doi.org/10.4103/0250-474X.40335 |
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author | Patel, D. M. Patel, M. M. |
author_facet | Patel, D. M. Patel, M. M. |
author_sort | Patel, D. M. |
collection | PubMed |
description | The purpose of this investigation was to develop fast dissolving tablets of etoricoxib. Granules containing etoricoxib, menthol, crospovidone, aspartame and mannitol were prepared by wet granulation technique. Menthol was sublimed from the granules by exposing the granules to vacuum. The porous granules were then compressed in to tablets. Alternatively, tablets were first prepared and later exposed to vacuum. The tablets were evaluated for percentage friability and disintegration time. A 3(2) full factorial design was applied to investigate the combined effect of 2 formulation variables: amount of menthol and crospovidone. The results of multiple regression analysis indicated that for obtaining fast dissolving tablets; optimum amount of menthol and higher percentage of crospovidone should be used. A surface response plots are also presented to graphically represent the effect of the independent variables on the percentage friability and disintegration time. The validity of a generated mathematical model was tested by preparing a checkpoint batch. Sublimation of menthol from tablets resulted in rapid disintegration as compared with the tablets prepared from granules that were exposed to vacuum. The optimized tablet formulation was compared with conventional marketed tablets for percentage drug dissolved in 30 min (Q(30)) and dissolution efficiency after 30 min (DE(30)). From the results, it was concluded that fast dissolving tablets with improved etoricoxib dissolution could be prepared by sublimation of tablets containing suitable subliming agent. |
format | Text |
id | pubmed-2852065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28520652010-04-13 Optimization of Fast Dissolving Etoricoxib Tablets Prepared by Sublimation Technique Patel, D. M. Patel, M. M. Indian J Pharm Sci Research Paper The purpose of this investigation was to develop fast dissolving tablets of etoricoxib. Granules containing etoricoxib, menthol, crospovidone, aspartame and mannitol were prepared by wet granulation technique. Menthol was sublimed from the granules by exposing the granules to vacuum. The porous granules were then compressed in to tablets. Alternatively, tablets were first prepared and later exposed to vacuum. The tablets were evaluated for percentage friability and disintegration time. A 3(2) full factorial design was applied to investigate the combined effect of 2 formulation variables: amount of menthol and crospovidone. The results of multiple regression analysis indicated that for obtaining fast dissolving tablets; optimum amount of menthol and higher percentage of crospovidone should be used. A surface response plots are also presented to graphically represent the effect of the independent variables on the percentage friability and disintegration time. The validity of a generated mathematical model was tested by preparing a checkpoint batch. Sublimation of menthol from tablets resulted in rapid disintegration as compared with the tablets prepared from granules that were exposed to vacuum. The optimized tablet formulation was compared with conventional marketed tablets for percentage drug dissolved in 30 min (Q(30)) and dissolution efficiency after 30 min (DE(30)). From the results, it was concluded that fast dissolving tablets with improved etoricoxib dissolution could be prepared by sublimation of tablets containing suitable subliming agent. Medknow Publications 2008 /pmc/articles/PMC2852065/ /pubmed/20390084 http://dx.doi.org/10.4103/0250-474X.40335 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Patel, D. M. Patel, M. M. Optimization of Fast Dissolving Etoricoxib Tablets Prepared by Sublimation Technique |
title | Optimization of Fast Dissolving Etoricoxib Tablets Prepared by Sublimation Technique |
title_full | Optimization of Fast Dissolving Etoricoxib Tablets Prepared by Sublimation Technique |
title_fullStr | Optimization of Fast Dissolving Etoricoxib Tablets Prepared by Sublimation Technique |
title_full_unstemmed | Optimization of Fast Dissolving Etoricoxib Tablets Prepared by Sublimation Technique |
title_short | Optimization of Fast Dissolving Etoricoxib Tablets Prepared by Sublimation Technique |
title_sort | optimization of fast dissolving etoricoxib tablets prepared by sublimation technique |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852065/ https://www.ncbi.nlm.nih.gov/pubmed/20390084 http://dx.doi.org/10.4103/0250-474X.40335 |
work_keys_str_mv | AT pateldm optimizationoffastdissolvingetoricoxibtabletspreparedbysublimationtechnique AT patelmm optimizationoffastdissolvingetoricoxibtabletspreparedbysublimationtechnique |