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Dynamics of serum antibodies to and load of porcine circovirus type 2 (PCV2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome

BACKGROUND: Despite that PMWS commonly affects pigs aged eight to sixteen weeks; most studies of PMWS have been conducted during the period before transfer to finishing herds. This study focused on PCV2 load and antibody dynamics in finishing herds with different PMWS status. METHODS: Sequentially c...

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Autores principales: Brunborg, Inger M, Fossum, Caroline, Lium, Bjørn, Blomqvist, Gunilla, Merlot, Elodie, Jørgensen, Anne, Eliasson-Selling, Lena, Rimstad, Espen, Jonassen, Christine M, Wallgren, Per
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852380/
https://www.ncbi.nlm.nih.gov/pubmed/20302632
http://dx.doi.org/10.1186/1751-0147-52-22
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author Brunborg, Inger M
Fossum, Caroline
Lium, Bjørn
Blomqvist, Gunilla
Merlot, Elodie
Jørgensen, Anne
Eliasson-Selling, Lena
Rimstad, Espen
Jonassen, Christine M
Wallgren, Per
author_facet Brunborg, Inger M
Fossum, Caroline
Lium, Bjørn
Blomqvist, Gunilla
Merlot, Elodie
Jørgensen, Anne
Eliasson-Selling, Lena
Rimstad, Espen
Jonassen, Christine M
Wallgren, Per
author_sort Brunborg, Inger M
collection PubMed
description BACKGROUND: Despite that PMWS commonly affects pigs aged eight to sixteen weeks; most studies of PMWS have been conducted during the period before transfer to finishing herds. This study focused on PCV2 load and antibody dynamics in finishing herds with different PMWS status. METHODS: Sequentially collected blood samples from 40 pigs in each of two Swedish (A and B) and one Norwegian (C) finishing herds were analysed for serum PCV2-load and -antibodies and saliva cortisol. The two Swedish herds differed in PMWS status, despite receiving animals from the same sow pool (multi-site production). However, the PMWS-deemed herd (A) had previously also received pigs from the spot market. ResultsThe initial serum PCV2 load was similar in the two Swedish herds. In herd A, it peaked after two weeks in the finishing herd and a high number of the pigs had serum PCV2 levels above 10(7 )per ml. The antibody titres increased continually with exception for the pigs that developed PMWS, that had initially low and then declining antibody levels. Pigs in the healthy herd B also expressed high titres of antibodies to PCV2 on arrival but remained at that level throughout the study whereas the viral load steadily decreased. No PCV2 antibodies and only low amounts of PCV2 DNA were detected in serum collected during the first five weeks in the PMWS-free herd C. Thereafter a peak in serum PCV2 load accompanied by an antibody response was recorded. PCV2 from the two Swedish herds grouped into genotype PCV2b whereas the Norwegian isolate grouped into PCV2a. Cortisol levels were lower in herd C than in herds A and B. CONCLUSIONS: The most obvious difference between the Swedish finishing herds and the Norwegian herd was the time of infection with PCV2 in relation to the time of allocation, as well as the genotype of PCV2. Clinical PMWS was preceded by low levels of serum antibodies and a high load of PCV2 but did not develop in all such animals. It is notable that herd A became affected by PMWS after errors in management routine, emphasising the importance of proper hygiene and general disease-preventing measures.
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spelling pubmed-28523802010-04-10 Dynamics of serum antibodies to and load of porcine circovirus type 2 (PCV2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome Brunborg, Inger M Fossum, Caroline Lium, Bjørn Blomqvist, Gunilla Merlot, Elodie Jørgensen, Anne Eliasson-Selling, Lena Rimstad, Espen Jonassen, Christine M Wallgren, Per Acta Vet Scand Research BACKGROUND: Despite that PMWS commonly affects pigs aged eight to sixteen weeks; most studies of PMWS have been conducted during the period before transfer to finishing herds. This study focused on PCV2 load and antibody dynamics in finishing herds with different PMWS status. METHODS: Sequentially collected blood samples from 40 pigs in each of two Swedish (A and B) and one Norwegian (C) finishing herds were analysed for serum PCV2-load and -antibodies and saliva cortisol. The two Swedish herds differed in PMWS status, despite receiving animals from the same sow pool (multi-site production). However, the PMWS-deemed herd (A) had previously also received pigs from the spot market. ResultsThe initial serum PCV2 load was similar in the two Swedish herds. In herd A, it peaked after two weeks in the finishing herd and a high number of the pigs had serum PCV2 levels above 10(7 )per ml. The antibody titres increased continually with exception for the pigs that developed PMWS, that had initially low and then declining antibody levels. Pigs in the healthy herd B also expressed high titres of antibodies to PCV2 on arrival but remained at that level throughout the study whereas the viral load steadily decreased. No PCV2 antibodies and only low amounts of PCV2 DNA were detected in serum collected during the first five weeks in the PMWS-free herd C. Thereafter a peak in serum PCV2 load accompanied by an antibody response was recorded. PCV2 from the two Swedish herds grouped into genotype PCV2b whereas the Norwegian isolate grouped into PCV2a. Cortisol levels were lower in herd C than in herds A and B. CONCLUSIONS: The most obvious difference between the Swedish finishing herds and the Norwegian herd was the time of infection with PCV2 in relation to the time of allocation, as well as the genotype of PCV2. Clinical PMWS was preceded by low levels of serum antibodies and a high load of PCV2 but did not develop in all such animals. It is notable that herd A became affected by PMWS after errors in management routine, emphasising the importance of proper hygiene and general disease-preventing measures. BioMed Central 2010-03-19 /pmc/articles/PMC2852380/ /pubmed/20302632 http://dx.doi.org/10.1186/1751-0147-52-22 Text en Copyright ©2010 Brunborg et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Brunborg, Inger M
Fossum, Caroline
Lium, Bjørn
Blomqvist, Gunilla
Merlot, Elodie
Jørgensen, Anne
Eliasson-Selling, Lena
Rimstad, Espen
Jonassen, Christine M
Wallgren, Per
Dynamics of serum antibodies to and load of porcine circovirus type 2 (PCV2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome
title Dynamics of serum antibodies to and load of porcine circovirus type 2 (PCV2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome
title_full Dynamics of serum antibodies to and load of porcine circovirus type 2 (PCV2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome
title_fullStr Dynamics of serum antibodies to and load of porcine circovirus type 2 (PCV2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome
title_full_unstemmed Dynamics of serum antibodies to and load of porcine circovirus type 2 (PCV2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome
title_short Dynamics of serum antibodies to and load of porcine circovirus type 2 (PCV2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome
title_sort dynamics of serum antibodies to and load of porcine circovirus type 2 (pcv2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852380/
https://www.ncbi.nlm.nih.gov/pubmed/20302632
http://dx.doi.org/10.1186/1751-0147-52-22
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