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Targeting TLR/IL-1R Signalling in Human Diseases
The members of Toll-like receptor/Interleukin (IL)-1 receptor (TLR/IL-1R) superfamily play a fundamental role in the immune response. These receptors detect microbial components and trigger complex signalling pathways that result in increased expression of multiple inflammatory genes. On the other h...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852602/ https://www.ncbi.nlm.nih.gov/pubmed/20396389 http://dx.doi.org/10.1155/2010/674363 |
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author | Loiarro, Maria Ruggiero, Vito Sette, Claudio |
author_facet | Loiarro, Maria Ruggiero, Vito Sette, Claudio |
author_sort | Loiarro, Maria |
collection | PubMed |
description | The members of Toll-like receptor/Interleukin (IL)-1 receptor (TLR/IL-1R) superfamily play a fundamental role in the immune response. These receptors detect microbial components and trigger complex signalling pathways that result in increased expression of multiple inflammatory genes. On the other hand, an aberrant activation of TLR/IL-1R signalling can promote the onset of inflammatory and autoimmune diseases, raising the interest in the development of therapeutic strategies for the control of their function. In this review, we illustrate the structural and functional features of TLR/IL-1R proteins and discuss some recent advances in the approaches undertaken to develop anti-inflammatory therapeutic drugs. In particular, we will focus on inhibitors, such as decoy peptides and synthetic mimetics, that interfere with protein-protein interactions between signalling molecules of the TLR/IL-1R superfamily. Given their central role in innate and adaptive immune responses, it is foreseen that pharmaceutical modulation of TLR/IL-1R signalling pathways by these drugs might yield clinical benefits in the treatment of inflammatory and autoimmune diseases. |
format | Text |
id | pubmed-2852602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28526022010-04-15 Targeting TLR/IL-1R Signalling in Human Diseases Loiarro, Maria Ruggiero, Vito Sette, Claudio Mediators Inflamm Review Article The members of Toll-like receptor/Interleukin (IL)-1 receptor (TLR/IL-1R) superfamily play a fundamental role in the immune response. These receptors detect microbial components and trigger complex signalling pathways that result in increased expression of multiple inflammatory genes. On the other hand, an aberrant activation of TLR/IL-1R signalling can promote the onset of inflammatory and autoimmune diseases, raising the interest in the development of therapeutic strategies for the control of their function. In this review, we illustrate the structural and functional features of TLR/IL-1R proteins and discuss some recent advances in the approaches undertaken to develop anti-inflammatory therapeutic drugs. In particular, we will focus on inhibitors, such as decoy peptides and synthetic mimetics, that interfere with protein-protein interactions between signalling molecules of the TLR/IL-1R superfamily. Given their central role in innate and adaptive immune responses, it is foreseen that pharmaceutical modulation of TLR/IL-1R signalling pathways by these drugs might yield clinical benefits in the treatment of inflammatory and autoimmune diseases. Hindawi Publishing Corporation 2010 2010-04-08 /pmc/articles/PMC2852602/ /pubmed/20396389 http://dx.doi.org/10.1155/2010/674363 Text en Copyright © 2010 Maria Loiarro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Loiarro, Maria Ruggiero, Vito Sette, Claudio Targeting TLR/IL-1R Signalling in Human Diseases |
title | Targeting TLR/IL-1R Signalling in Human Diseases |
title_full | Targeting TLR/IL-1R Signalling in Human Diseases |
title_fullStr | Targeting TLR/IL-1R Signalling in Human Diseases |
title_full_unstemmed | Targeting TLR/IL-1R Signalling in Human Diseases |
title_short | Targeting TLR/IL-1R Signalling in Human Diseases |
title_sort | targeting tlr/il-1r signalling in human diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852602/ https://www.ncbi.nlm.nih.gov/pubmed/20396389 http://dx.doi.org/10.1155/2010/674363 |
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