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The Bright and the Dark Sides of DNA Repair in Stem Cells
DNA repair is a double-edged sword in stem cells. It protects normal stem cells in both embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact genomes into new tissues. Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells. Upon diff...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852612/ https://www.ncbi.nlm.nih.gov/pubmed/20396397 http://dx.doi.org/10.1155/2010/845396 |
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author | Frosina, Guido |
author_facet | Frosina, Guido |
author_sort | Frosina, Guido |
collection | PubMed |
description | DNA repair is a double-edged sword in stem cells. It protects normal stem cells in both embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact genomes into new tissues. Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells. Upon differentiation, a certain degree of somatic mutations becomes more acceptable and, consequently, DNA repair dims. DNA repair turns into a problem when stem cells transform and become cancerous. Transformed stem cells drive growth of a number of tumours (e.g., high grade gliomas) and being particularly resistant to chemo- and radiotherapeutic agents often cause relapses. The contribution of DNA repair to resistance of these tumour-driving cells is the subject of intense research, in order to find novel agents that may sensitize them to chemotherapy and radiotherapy. |
format | Text |
id | pubmed-2852612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28526122010-04-15 The Bright and the Dark Sides of DNA Repair in Stem Cells Frosina, Guido J Biomed Biotechnol Review Article DNA repair is a double-edged sword in stem cells. It protects normal stem cells in both embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact genomes into new tissues. Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells. Upon differentiation, a certain degree of somatic mutations becomes more acceptable and, consequently, DNA repair dims. DNA repair turns into a problem when stem cells transform and become cancerous. Transformed stem cells drive growth of a number of tumours (e.g., high grade gliomas) and being particularly resistant to chemo- and radiotherapeutic agents often cause relapses. The contribution of DNA repair to resistance of these tumour-driving cells is the subject of intense research, in order to find novel agents that may sensitize them to chemotherapy and radiotherapy. Hindawi Publishing Corporation 2010 2010-04-08 /pmc/articles/PMC2852612/ /pubmed/20396397 http://dx.doi.org/10.1155/2010/845396 Text en Copyright © 2010 Guido Frosina. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Frosina, Guido The Bright and the Dark Sides of DNA Repair in Stem Cells |
title | The Bright and the Dark Sides of DNA Repair in Stem Cells |
title_full | The Bright and the Dark Sides of DNA Repair in Stem Cells |
title_fullStr | The Bright and the Dark Sides of DNA Repair in Stem Cells |
title_full_unstemmed | The Bright and the Dark Sides of DNA Repair in Stem Cells |
title_short | The Bright and the Dark Sides of DNA Repair in Stem Cells |
title_sort | bright and the dark sides of dna repair in stem cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852612/ https://www.ncbi.nlm.nih.gov/pubmed/20396397 http://dx.doi.org/10.1155/2010/845396 |
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