Caged mitochondrial uncouplers that are released in response to hydrogen peroxide

Caged versions of the most common mitochondrial uncouplers (proton translocators) have been prepared that sense the reactive oxygen species (ROS) hydrogen peroxide to release the uncouplers 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) from caged states with se...

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Detalles Bibliográficos
Autores principales: Quin, Caroline, Robertson, Linsey, McQuaker, Stephen J., Price, Nicholas C., Brand, Martin D., Hartley, Richard C.
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852674/
https://www.ncbi.nlm.nih.gov/pubmed/20418941
http://dx.doi.org/10.1016/j.tet.2010.01.103
Descripción
Sumario:Caged versions of the most common mitochondrial uncouplers (proton translocators) have been prepared that sense the reactive oxygen species (ROS) hydrogen peroxide to release the uncouplers 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) from caged states with second order rate constants of 10 (±0.8) M(−1) s(−1) and 64.8 (±0.6) M(−1) s(−1), respectively. The trigger mechanism involves conversion of an arylboronate into a phenol followed by fragmentation. Hydrogen peroxide-activated uncouplers may be useful for studying the biological process of ageing.

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