Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii

Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosineiodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of th...

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Autores principales: Aiello, Anna, Fattorusso, Ernesto, Imperatore, Concetta, Menna, Marialuisa, Müller, Werner E.G.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852839/
https://www.ncbi.nlm.nih.gov/pubmed/20390106
http://dx.doi.org/10.3390/md8020285
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author Aiello, Anna
Fattorusso, Ernesto
Imperatore, Concetta
Menna, Marialuisa
Müller, Werner E.G.
author_facet Aiello, Anna
Fattorusso, Ernesto
Imperatore, Concetta
Menna, Marialuisa
Müller, Werner E.G.
author_sort Aiello, Anna
collection PubMed
description Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosineiodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis. Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC(50) of 7.75 μg/mL.
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spelling pubmed-28528392010-04-13 Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii Aiello, Anna Fattorusso, Ernesto Imperatore, Concetta Menna, Marialuisa Müller, Werner E.G. Mar Drugs Article Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosineiodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis. Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC(50) of 7.75 μg/mL. Molecular Diversity Preservation International 2010-02-21 /pmc/articles/PMC2852839/ /pubmed/20390106 http://dx.doi.org/10.3390/md8020285 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Aiello, Anna
Fattorusso, Ernesto
Imperatore, Concetta
Menna, Marialuisa
Müller, Werner E.G.
Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii
title Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii
title_full Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii
title_fullStr Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii
title_full_unstemmed Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii
title_short Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii
title_sort iodocionin, a cytotoxic iodinated metabolite from the mediterranean ascidian ciona edwardsii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852839/
https://www.ncbi.nlm.nih.gov/pubmed/20390106
http://dx.doi.org/10.3390/md8020285
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AT imperatoreconcetta iodocioninacytotoxiciodinatedmetabolitefromthemediterraneanascidiancionaedwardsii
AT mennamarialuisa iodocioninacytotoxiciodinatedmetabolitefromthemediterraneanascidiancionaedwardsii
AT mullerwernereg iodocioninacytotoxiciodinatedmetabolitefromthemediterraneanascidiancionaedwardsii

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