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Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity

Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three...

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Detalles Bibliográficos
Autores principales: Simon-Levert, Annabel, Menniti, Christophe, Soulère, Laurent, Genevière, Anne-Marie, Barthomeuf, Chantal, Banaigs, Bernard, Witczak, Anne
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852842/
https://www.ncbi.nlm.nih.gov/pubmed/20390109
http://dx.doi.org/10.3390/md8020347
Descripción
Sumario:Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.