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Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity

Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three...

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Detalles Bibliográficos
Autores principales: Simon-Levert, Annabel, Menniti, Christophe, Soulère, Laurent, Genevière, Anne-Marie, Barthomeuf, Chantal, Banaigs, Bernard, Witczak, Anne
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852842/
https://www.ncbi.nlm.nih.gov/pubmed/20390109
http://dx.doi.org/10.3390/md8020347
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author Simon-Levert, Annabel
Menniti, Christophe
Soulère, Laurent
Genevière, Anne-Marie
Barthomeuf, Chantal
Banaigs, Bernard
Witczak, Anne
author_facet Simon-Levert, Annabel
Menniti, Christophe
Soulère, Laurent
Genevière, Anne-Marie
Barthomeuf, Chantal
Banaigs, Bernard
Witczak, Anne
author_sort Simon-Levert, Annabel
collection PubMed
description Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.
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spelling pubmed-28528422010-04-13 Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity Simon-Levert, Annabel Menniti, Christophe Soulère, Laurent Genevière, Anne-Marie Barthomeuf, Chantal Banaigs, Bernard Witczak, Anne Mar Drugs Article Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells. Molecular Diversity Preservation International 2010-02-23 /pmc/articles/PMC2852842/ /pubmed/20390109 http://dx.doi.org/10.3390/md8020347 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Simon-Levert, Annabel
Menniti, Christophe
Soulère, Laurent
Genevière, Anne-Marie
Barthomeuf, Chantal
Banaigs, Bernard
Witczak, Anne
Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity
title Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity
title_full Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity
title_fullStr Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity
title_full_unstemmed Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity
title_short Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity
title_sort marine natural meroterpenes: synthesis and antiproliferative activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852842/
https://www.ncbi.nlm.nih.gov/pubmed/20390109
http://dx.doi.org/10.3390/md8020347
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