Cargando…
Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity
Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852842/ https://www.ncbi.nlm.nih.gov/pubmed/20390109 http://dx.doi.org/10.3390/md8020347 |
_version_ | 1782179993757941760 |
---|---|
author | Simon-Levert, Annabel Menniti, Christophe Soulère, Laurent Genevière, Anne-Marie Barthomeuf, Chantal Banaigs, Bernard Witczak, Anne |
author_facet | Simon-Levert, Annabel Menniti, Christophe Soulère, Laurent Genevière, Anne-Marie Barthomeuf, Chantal Banaigs, Bernard Witczak, Anne |
author_sort | Simon-Levert, Annabel |
collection | PubMed |
description | Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells. |
format | Text |
id | pubmed-2852842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International |
record_format | MEDLINE/PubMed |
spelling | pubmed-28528422010-04-13 Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity Simon-Levert, Annabel Menniti, Christophe Soulère, Laurent Genevière, Anne-Marie Barthomeuf, Chantal Banaigs, Bernard Witczak, Anne Mar Drugs Article Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells. Molecular Diversity Preservation International 2010-02-23 /pmc/articles/PMC2852842/ /pubmed/20390109 http://dx.doi.org/10.3390/md8020347 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Simon-Levert, Annabel Menniti, Christophe Soulère, Laurent Genevière, Anne-Marie Barthomeuf, Chantal Banaigs, Bernard Witczak, Anne Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity |
title | Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity |
title_full | Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity |
title_fullStr | Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity |
title_full_unstemmed | Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity |
title_short | Marine Natural Meroterpenes: Synthesis and Antiproliferative Activity |
title_sort | marine natural meroterpenes: synthesis and antiproliferative activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852842/ https://www.ncbi.nlm.nih.gov/pubmed/20390109 http://dx.doi.org/10.3390/md8020347 |
work_keys_str_mv | AT simonlevertannabel marinenaturalmeroterpenessynthesisandantiproliferativeactivity AT mennitichristophe marinenaturalmeroterpenessynthesisandantiproliferativeactivity AT soulerelaurent marinenaturalmeroterpenessynthesisandantiproliferativeactivity AT geneviereannemarie marinenaturalmeroterpenessynthesisandantiproliferativeactivity AT barthomeufchantal marinenaturalmeroterpenessynthesisandantiproliferativeactivity AT banaigsbernard marinenaturalmeroterpenessynthesisandantiproliferativeactivity AT witczakanne marinenaturalmeroterpenessynthesisandantiproliferativeactivity |