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New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals
Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively....
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852843/ https://www.ncbi.nlm.nih.gov/pubmed/20390110 http://dx.doi.org/10.3390/md8020359 |
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author | Bonnard, Isabelle Jhaumeer-Laulloo, Sabina B. Bontemps, Nataly Banaigs, Bernard Aknin, Maurice |
author_facet | Bonnard, Isabelle Jhaumeer-Laulloo, Sabina B. Bontemps, Nataly Banaigs, Bernard Aknin, Maurice |
author_sort | Bonnard, Isabelle |
collection | PubMed |
description | Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 1–3 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase. |
format | Text |
id | pubmed-2852843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International |
record_format | MEDLINE/PubMed |
spelling | pubmed-28528432010-04-13 New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals Bonnard, Isabelle Jhaumeer-Laulloo, Sabina B. Bontemps, Nataly Banaigs, Bernard Aknin, Maurice Mar Drugs Article Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 1–3 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase. Molecular Diversity Preservation International 2010-02-23 /pmc/articles/PMC2852843/ /pubmed/20390110 http://dx.doi.org/10.3390/md8020359 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Bonnard, Isabelle Jhaumeer-Laulloo, Sabina B. Bontemps, Nataly Banaigs, Bernard Aknin, Maurice New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals |
title | New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals |
title_full | New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals |
title_fullStr | New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals |
title_full_unstemmed | New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals |
title_short | New Lobane and Cembrane Diterpenes from Two Comorian Soft Corals |
title_sort | new lobane and cembrane diterpenes from two comorian soft corals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852843/ https://www.ncbi.nlm.nih.gov/pubmed/20390110 http://dx.doi.org/10.3390/md8020359 |
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