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Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges
Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp. strains from Mediterranean sponges, on their secondary metabol...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852844/ https://www.ncbi.nlm.nih.gov/pubmed/20390111 http://dx.doi.org/10.3390/md8020373 |
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author | Pimentel-Elardo, Sheila Marie Kozytska, Svitlana Bugni, Tim S. Ireland, Chris M. Moll, Heidrun Hentschel, Ute |
author_facet | Pimentel-Elardo, Sheila Marie Kozytska, Svitlana Bugni, Tim S. Ireland, Chris M. Moll, Heidrun Hentschel, Ute |
author_sort | Pimentel-Elardo, Sheila Marie |
collection | PubMed |
description | Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp. strains from Mediterranean sponges, on their secondary metabolite production and on their screening for anti-infective activities. Bioassay-guided isolation and purification yielded three previously known compounds namely, cyclic depsipeptide valinomycin, indolocarbazole alkaloid staurosporine and butenolide. This is the first report of the isolation of valinomycin from a marine source. These compounds exhibited novel anti-parasitic activities specifically against Leishmania major (valinomycin IC(50) < 0.11 μM; staurosporine IC(50) 5.30 μM) and Trypanosoma brucei brucei (valinomycin IC(50) 0.0032 μM; staurosporine IC(50) 0.022 μM; butenolide IC(50) 31.77 μM). These results underscore the potential of marine actinomycetes to produce bioactive compounds as well as the re-evaluation of previously known compounds for novel anti-infective activities. |
format | Text |
id | pubmed-2852844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International |
record_format | MEDLINE/PubMed |
spelling | pubmed-28528442010-04-13 Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges Pimentel-Elardo, Sheila Marie Kozytska, Svitlana Bugni, Tim S. Ireland, Chris M. Moll, Heidrun Hentschel, Ute Mar Drugs Communication Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp. strains from Mediterranean sponges, on their secondary metabolite production and on their screening for anti-infective activities. Bioassay-guided isolation and purification yielded three previously known compounds namely, cyclic depsipeptide valinomycin, indolocarbazole alkaloid staurosporine and butenolide. This is the first report of the isolation of valinomycin from a marine source. These compounds exhibited novel anti-parasitic activities specifically against Leishmania major (valinomycin IC(50) < 0.11 μM; staurosporine IC(50) 5.30 μM) and Trypanosoma brucei brucei (valinomycin IC(50) 0.0032 μM; staurosporine IC(50) 0.022 μM; butenolide IC(50) 31.77 μM). These results underscore the potential of marine actinomycetes to produce bioactive compounds as well as the re-evaluation of previously known compounds for novel anti-infective activities. Molecular Diversity Preservation International 2010-02-23 /pmc/articles/PMC2852844/ /pubmed/20390111 http://dx.doi.org/10.3390/md8020373 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Communication Pimentel-Elardo, Sheila Marie Kozytska, Svitlana Bugni, Tim S. Ireland, Chris M. Moll, Heidrun Hentschel, Ute Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges |
title | Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges |
title_full | Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges |
title_fullStr | Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges |
title_full_unstemmed | Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges |
title_short | Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges |
title_sort | anti-parasitic compounds from streptomyces sp. strains isolated from mediterranean sponges |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852844/ https://www.ncbi.nlm.nih.gov/pubmed/20390111 http://dx.doi.org/10.3390/md8020373 |
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