Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine

Olmesartan medoxomil (OM) is a prodrug type angiotensin II type 1 receptor antagonist widely prescribed as an antihypertensive agent. Herein, we describe the identification and characterization of the OM bioactivating enzyme that hydrolyzes the prodrug and converts to its pharmacologically active me...

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Detalles Bibliográficos
Autores principales: Ishizuka, Tomoko, Fujimori, Izumi, Kato, Mitsunori, Noji-Sakikawa, Chisa, Saito, Motoko, Yoshigae, Yasushi, Kubota, Kazuishi, Kurihara, Atsushi, Izumi, Takashi, Ikeda, Toshihiko, Okazaki, Osamu
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852926/
https://www.ncbi.nlm.nih.gov/pubmed/20177059
http://dx.doi.org/10.1074/jbc.M109.072629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852926/
https://www.ncbi.nlm.nih.gov/pubmed/20177059
http://dx.doi.org/10.1074/jbc.M109.072629

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