Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China

BACKGROUND: Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear. METHODS: We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai. RESULTS: The ef...

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Detalles Bibliográficos
Autores principales: Andreotti, G, Hou, L, Gao, Y-T, Brinton, L A, Rashid, A, Chen, J, Shen, M-C, Wang, B-S, Han, T-Q, Zhang, B-H, Sakoda, L C, Fraumeni, J F, Hsing, A W
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853091/
https://www.ncbi.nlm.nih.gov/pubmed/20216539
http://dx.doi.org/10.1038/sj.bjc.6605597
Descripción
Sumario:BACKGROUND: Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear. METHODS: We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai. RESULTS: The effects of parity (odds ratios, OR(⩾3 vs 1 child)=2.0, 95% confidence interval (CI) 0.7–5.1), younger age at first birth (OR(per 1-year decrease)=1.2, 95% CI 0.99–1.6), and older age at menarche (OR(per 1-year increase)=1.4, 95% CI 1.1–1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant. CONCLUSION: Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones.

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