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Homologous over-extension: a challenge for iterative similarity searches

We have characterized a novel type of PSI-BLAST error, homologous over-extension (HOE), using embedded PFAM domain queries on searches against a reference library containing Pfam-annotated UniProt sequences and random synthetic sequences. PSI-BLAST makes two types of errors: alignments to non-homolo...

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Detalles Bibliográficos
Autores principales:	Gonzalez, Mileidy W., Pearson, William R.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853128/ https://www.ncbi.nlm.nih.gov/pubmed/20064877 http://dx.doi.org/10.1093/nar/gkp1219

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