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Asthma: Clinical expression and molecular mechanisms

Asthma is a complex disorder that displays heterogeneity and variability in its clinical expression both acutely and chronically. This heterogeneity is influenced by multiple factors including age, sex, socioeconomic status, race and/or ethnicity, and gene by environment interactions. Presently, no...

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Detalles Bibliográficos
Autores principales: Lemanske, Robert F., Busse, William W.
Formato: Texto
Lenguaje:English
Publicado: American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853245/
https://www.ncbi.nlm.nih.gov/pubmed/20176271
http://dx.doi.org/10.1016/j.jaci.2009.10.047
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author Lemanske, Robert F.
Busse, William W.
author_facet Lemanske, Robert F.
Busse, William W.
author_sort Lemanske, Robert F.
collection PubMed
description Asthma is a complex disorder that displays heterogeneity and variability in its clinical expression both acutely and chronically. This heterogeneity is influenced by multiple factors including age, sex, socioeconomic status, race and/or ethnicity, and gene by environment interactions. Presently, no precise physiologic, immunologic, or histologic characteristics can be used to definitively make a diagnosis of asthma, and therefore the diagnosis is often made on a clinical basis related to symptom patterns (airways obstruction and hyperresponsiveness) and responses to therapy (partial or complete reversibility) over time. Although current treatment modalities are capable of producing control of symptoms and improvements in pulmonary function in the majority of patients, acute and often severe exacerbations still occur and contribute significantly to both the morbidity and mortality of asthma in all age groups. This review will highlight some of the important clinical features of asthma and emphasize recent advances in both pathophysiology and treatment.
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spelling pubmed-28532452011-02-01 Asthma: Clinical expression and molecular mechanisms Lemanske, Robert F. Busse, William W. J Allergy Clin Immunol Chapter 8 Asthma is a complex disorder that displays heterogeneity and variability in its clinical expression both acutely and chronically. This heterogeneity is influenced by multiple factors including age, sex, socioeconomic status, race and/or ethnicity, and gene by environment interactions. Presently, no precise physiologic, immunologic, or histologic characteristics can be used to definitively make a diagnosis of asthma, and therefore the diagnosis is often made on a clinical basis related to symptom patterns (airways obstruction and hyperresponsiveness) and responses to therapy (partial or complete reversibility) over time. Although current treatment modalities are capable of producing control of symptoms and improvements in pulmonary function in the majority of patients, acute and often severe exacerbations still occur and contribute significantly to both the morbidity and mortality of asthma in all age groups. This review will highlight some of the important clinical features of asthma and emphasize recent advances in both pathophysiology and treatment. American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. 2010-02 2010-02-20 /pmc/articles/PMC2853245/ /pubmed/20176271 http://dx.doi.org/10.1016/j.jaci.2009.10.047 Text en Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Chapter 8
Lemanske, Robert F.
Busse, William W.
Asthma: Clinical expression and molecular mechanisms
title Asthma: Clinical expression and molecular mechanisms
title_full Asthma: Clinical expression and molecular mechanisms
title_fullStr Asthma: Clinical expression and molecular mechanisms
title_full_unstemmed Asthma: Clinical expression and molecular mechanisms
title_short Asthma: Clinical expression and molecular mechanisms
title_sort asthma: clinical expression and molecular mechanisms
topic Chapter 8
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853245/
https://www.ncbi.nlm.nih.gov/pubmed/20176271
http://dx.doi.org/10.1016/j.jaci.2009.10.047
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