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The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents

BACKGROUND: Alcohol abuse is associated with sleep problems, which are often linked to circadian rhythm disturbances. Previous studies have separately examined the effects of mutations in the clock gene PER2 on alcohol consumption and sleep problems. Here we hypothesized that an allelic variation in...

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Autores principales: Comasco, Erika, Nordquist, Niklas, Göktürk, Camilla, Åslund, Cecilia, Hallman, Jarmila, Oreland, Lars, Nilsson, Kent W.
Formato: Texto
Lenguaje:English
Publicado: Informa Healthcare 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853353/
https://www.ncbi.nlm.nih.gov/pubmed/20187847
http://dx.doi.org/10.3109/03009731003597127
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author Comasco, Erika
Nordquist, Niklas
Göktürk, Camilla
Åslund, Cecilia
Hallman, Jarmila
Oreland, Lars
Nilsson, Kent W.
author_facet Comasco, Erika
Nordquist, Niklas
Göktürk, Camilla
Åslund, Cecilia
Hallman, Jarmila
Oreland, Lars
Nilsson, Kent W.
author_sort Comasco, Erika
collection PubMed
description BACKGROUND: Alcohol abuse is associated with sleep problems, which are often linked to circadian rhythm disturbances. Previous studies have separately examined the effects of mutations in the clock gene PER2 on alcohol consumption and sleep problems. Here we hypothesized that an allelic variation in the PER2 gene is associated with alcohol consumption in interaction with sleep problems among adolescents. METHODS: The Survey of Adolescent Life and Health in Västmanland 2006, a Swedish county, including 1254 students 17–18 years old, was used as a population-representative sample of adolescents. We investigated the PER2 Single Nucleotide polymorphism (SNP) 10870 (A/G) in the cohort together with an assessment of alcohol consumption according to the AUDIT-C questionnaire, and sleep problems using a survey consisting of 18 items. Furthermore, we carried out an exploratory analysis on the PER2 Single Nucleotide Polymorphism 10870 polymorphism in a group of severely alcoholic females. RESULTS: We found a significant association of the SNP 10870 in adolescent boys, where the genotype AA, in the presence of several and frequent sleep problems, was associated with increased alcohol consumption. Among adolescent girls, only sleep problems were related to alcohol consumption. A non-significant trend was observed among the severely alcoholic females, with the G allele being over-represented in the severely alcoholic females group in comparision to the control females. CONCLUSION: These results indicate that PER2 gene variation is associated with alcohol consumption in interaction with sleep problems among Swedish adolescent boys.
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spelling pubmed-28533532010-05-19 The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents Comasco, Erika Nordquist, Niklas Göktürk, Camilla Åslund, Cecilia Hallman, Jarmila Oreland, Lars Nilsson, Kent W. Ups J Med Sci Original Article BACKGROUND: Alcohol abuse is associated with sleep problems, which are often linked to circadian rhythm disturbances. Previous studies have separately examined the effects of mutations in the clock gene PER2 on alcohol consumption and sleep problems. Here we hypothesized that an allelic variation in the PER2 gene is associated with alcohol consumption in interaction with sleep problems among adolescents. METHODS: The Survey of Adolescent Life and Health in Västmanland 2006, a Swedish county, including 1254 students 17–18 years old, was used as a population-representative sample of adolescents. We investigated the PER2 Single Nucleotide polymorphism (SNP) 10870 (A/G) in the cohort together with an assessment of alcohol consumption according to the AUDIT-C questionnaire, and sleep problems using a survey consisting of 18 items. Furthermore, we carried out an exploratory analysis on the PER2 Single Nucleotide Polymorphism 10870 polymorphism in a group of severely alcoholic females. RESULTS: We found a significant association of the SNP 10870 in adolescent boys, where the genotype AA, in the presence of several and frequent sleep problems, was associated with increased alcohol consumption. Among adolescent girls, only sleep problems were related to alcohol consumption. A non-significant trend was observed among the severely alcoholic females, with the G allele being over-represented in the severely alcoholic females group in comparision to the control females. CONCLUSION: These results indicate that PER2 gene variation is associated with alcohol consumption in interaction with sleep problems among Swedish adolescent boys. Informa Healthcare 2010-03 2010-03-10 /pmc/articles/PMC2853353/ /pubmed/20187847 http://dx.doi.org/10.3109/03009731003597127 Text en © Upsala Medical Society http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Original Article
Comasco, Erika
Nordquist, Niklas
Göktürk, Camilla
Åslund, Cecilia
Hallman, Jarmila
Oreland, Lars
Nilsson, Kent W.
The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents
title The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents
title_full The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents
title_fullStr The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents
title_full_unstemmed The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents
title_short The clock gene PER2 and sleep problems: Association with alcohol consumption among Swedish adolescents
title_sort clock gene per2 and sleep problems: association with alcohol consumption among swedish adolescents
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853353/
https://www.ncbi.nlm.nih.gov/pubmed/20187847
http://dx.doi.org/10.3109/03009731003597127
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