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"Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression"
BACKGROUND: In damaged organs tissue repair and replacement of cells by connective tissue provokes a response of fibroblasts to cellular stress factors such as hypoxia. MicroRNAs (miRNA) are small non-coding RNA molecules which bind to their mRNA targets which eventually lead to repression of transl...
Autores principales: | Muth, Michaela, Theophile, Katharina, Hussein, Kais, Jacobi, Christoph, Kreipe, Hans, Bock, Oliver |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853517/ https://www.ncbi.nlm.nih.gov/pubmed/20356416 http://dx.doi.org/10.1186/1479-5876-8-33 |
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