Role of the Proteasome in Excitotoxicity-Induced Cleavage of Glutamic Acid Decarboxylase in Cultured Hippocampal Neurons

Glutamic acid decarboxylase is responsible for synthesizing GABA, the major inhibitory neurotransmitter, and exists in two isoforms—GAD65 and GAD67. The enzyme is cleaved under excitotoxic conditions, but the mechanisms involved and the functional consequences are not fully elucidated. We found that...

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Detalles Bibliográficos
Autores principales: Baptista, Márcio S., Melo, Carlos V., Armelão, Mário, Herrmann, Dennis, Pimentel, Diogo O., Leal, Graciano, Caldeira, Margarida V., Bahr, Ben A., Bengtson, Mário, Almeida, Ramiro D., Duarte, Carlos B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853570/
https://www.ncbi.nlm.nih.gov/pubmed/20405034
http://dx.doi.org/10.1371/journal.pone.0010139

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