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Cell-Extrinsic Defective Lymphocyte Development in Lmna(-/-) Mice
BACKGROUND: Mutations in the LMNA gene, which encodes all A-type lamins, result in a variety of human diseases termed laminopathies. Lmna(-/-) mice appear normal at birth but become runted as early as 2 weeks of age and develop multiple tissue defects that mimic some aspects of human laminopathies....
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853576/ https://www.ncbi.nlm.nih.gov/pubmed/20405040 http://dx.doi.org/10.1371/journal.pone.0010127 |