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Clinical and Virological Features of Dengue in Vietnamese Infants

BACKGROUND: Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised. METHODOLOGY/PRINCIPAL FINDINGS: This prospect...

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Autores principales: Bich Chau, Tran Nguyen, Anders, Katherine L., Lien, Le Bich, Hung, Nguyen Thanh, Minh Hieu, Lu Thi, Tuan, Nguyen Minh, Thuy, Tran Thi, Phuong, Le Thi, Hong Tham, Nguyen Thi, Lanh, Mai Ngoc, Farrar, Jeremy J., Whitehead, Stephen S., Simmons, Cameron P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854125/
https://www.ncbi.nlm.nih.gov/pubmed/20405057
http://dx.doi.org/10.1371/journal.pntd.0000657
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author Bich Chau, Tran Nguyen
Anders, Katherine L.
Lien, Le Bich
Hung, Nguyen Thanh
Minh Hieu, Lu Thi
Tuan, Nguyen Minh
Thuy, Tran Thi
Phuong, Le Thi
Hong Tham, Nguyen Thi
Lanh, Mai Ngoc
Farrar, Jeremy J.
Whitehead, Stephen S.
Simmons, Cameron P.
author_facet Bich Chau, Tran Nguyen
Anders, Katherine L.
Lien, Le Bich
Hung, Nguyen Thanh
Minh Hieu, Lu Thi
Tuan, Nguyen Minh
Thuy, Tran Thi
Phuong, Le Thi
Hong Tham, Nguyen Thi
Lanh, Mai Ngoc
Farrar, Jeremy J.
Whitehead, Stephen S.
Simmons, Cameron P.
author_sort Bich Chau, Tran Nguyen
collection PubMed
description BACKGROUND: Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised. METHODOLOGY/PRINCIPAL FINDINGS: This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on clinical suspicion of dengue had a serologically confirmed dengue virus (DENV) infection. Almost all were primary dengue infections and 80% of the infants developed DHF/DSS. At the time of presentation and during hospitalization, the clinical signs and symptoms in infants with dengue were difficult to distinguish from those with other febrile illnesses, suggesting that in infants early laboratory confirmation could assist appropriate management. Detection of plasma NS1 antigen was found to be a sensitive marker of acute dengue in infants with primary infection, especially in the first few days of illness. CONCLUSIONS/SIGNIFICANCE: Collectively, these results provide a systematic description of the clinical features of dengue in infants and highlight the value of NS1 detection for diagnosis.
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spelling pubmed-28541252010-04-19 Clinical and Virological Features of Dengue in Vietnamese Infants Bich Chau, Tran Nguyen Anders, Katherine L. Lien, Le Bich Hung, Nguyen Thanh Minh Hieu, Lu Thi Tuan, Nguyen Minh Thuy, Tran Thi Phuong, Le Thi Hong Tham, Nguyen Thi Lanh, Mai Ngoc Farrar, Jeremy J. Whitehead, Stephen S. Simmons, Cameron P. PLoS Negl Trop Dis Research Article BACKGROUND: Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised. METHODOLOGY/PRINCIPAL FINDINGS: This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on clinical suspicion of dengue had a serologically confirmed dengue virus (DENV) infection. Almost all were primary dengue infections and 80% of the infants developed DHF/DSS. At the time of presentation and during hospitalization, the clinical signs and symptoms in infants with dengue were difficult to distinguish from those with other febrile illnesses, suggesting that in infants early laboratory confirmation could assist appropriate management. Detection of plasma NS1 antigen was found to be a sensitive marker of acute dengue in infants with primary infection, especially in the first few days of illness. CONCLUSIONS/SIGNIFICANCE: Collectively, these results provide a systematic description of the clinical features of dengue in infants and highlight the value of NS1 detection for diagnosis. Public Library of Science 2010-04-13 /pmc/articles/PMC2854125/ /pubmed/20405057 http://dx.doi.org/10.1371/journal.pntd.0000657 Text en This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Bich Chau, Tran Nguyen
Anders, Katherine L.
Lien, Le Bich
Hung, Nguyen Thanh
Minh Hieu, Lu Thi
Tuan, Nguyen Minh
Thuy, Tran Thi
Phuong, Le Thi
Hong Tham, Nguyen Thi
Lanh, Mai Ngoc
Farrar, Jeremy J.
Whitehead, Stephen S.
Simmons, Cameron P.
Clinical and Virological Features of Dengue in Vietnamese Infants
title Clinical and Virological Features of Dengue in Vietnamese Infants
title_full Clinical and Virological Features of Dengue in Vietnamese Infants
title_fullStr Clinical and Virological Features of Dengue in Vietnamese Infants
title_full_unstemmed Clinical and Virological Features of Dengue in Vietnamese Infants
title_short Clinical and Virological Features of Dengue in Vietnamese Infants
title_sort clinical and virological features of dengue in vietnamese infants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854125/
https://www.ncbi.nlm.nih.gov/pubmed/20405057
http://dx.doi.org/10.1371/journal.pntd.0000657
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