A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

BACKGROUND: The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this metabolic pathway is mediated by hexokinase (TbHK), an enzyme essential to the parasite that transfers the γ-phospho of ATP to a he...

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Detalles Bibliográficos
Autores principales: Sharlow, Elizabeth R., Lyda, Todd A., Dodson, Heidi C., Mustata, Gabriela, Morris, Meredith T., Leimgruber, Stephanie S., Lee, Kuo-Hsiung, Kashiwada, Yoshiki, Close, David, Lazo, John S., Morris, James C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854128/
https://www.ncbi.nlm.nih.gov/pubmed/20405000
http://dx.doi.org/10.1371/journal.pntd.0000659

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