In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains

The in vitro activity of tigecycline was determined using a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 202), including 33 livestock-associated strains. Susceptibility testing was performed using the Etest system. Among the 202 MRSA strains, three (1.5...

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Autores principales: Verkade, E. J. M., Verhulst, C. J. M. M., Huijsdens, X. W., Kluytmans, J. A. J. W.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854363/
https://www.ncbi.nlm.nih.gov/pubmed/20186450
http://dx.doi.org/10.1007/s10096-010-0886-2
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author Verkade, E. J. M.
Verhulst, C. J. M. M.
Huijsdens, X. W.
Kluytmans, J. A. J. W.
author_facet Verkade, E. J. M.
Verhulst, C. J. M. M.
Huijsdens, X. W.
Kluytmans, J. A. J. W.
author_sort Verkade, E. J. M.
collection PubMed
description The in vitro activity of tigecycline was determined using a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 202), including 33 livestock-associated strains. Susceptibility testing was performed using the Etest system. Among the 202 MRSA strains, three (1.5%) had a minimum inhibitory concentration (MIC) value for tigecycline greater than 0.5 mg/l, which are considered to be resistant. When these strains were tested using Iso-Sensitest medium, the MICs were substantially lower and no resistance was found. This discrepancy warrants further investigations into the preferred test conditions for tigecycline. In conclusion, tigecycline showed good activity against MRSA strains in vitro.
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spelling pubmed-28543632010-04-21 In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains Verkade, E. J. M. Verhulst, C. J. M. M. Huijsdens, X. W. Kluytmans, J. A. J. W. Eur J Clin Microbiol Infect Dis Article The in vitro activity of tigecycline was determined using a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 202), including 33 livestock-associated strains. Susceptibility testing was performed using the Etest system. Among the 202 MRSA strains, three (1.5%) had a minimum inhibitory concentration (MIC) value for tigecycline greater than 0.5 mg/l, which are considered to be resistant. When these strains were tested using Iso-Sensitest medium, the MICs were substantially lower and no resistance was found. This discrepancy warrants further investigations into the preferred test conditions for tigecycline. In conclusion, tigecycline showed good activity against MRSA strains in vitro. Springer-Verlag 2010-02-26 2010 /pmc/articles/PMC2854363/ /pubmed/20186450 http://dx.doi.org/10.1007/s10096-010-0886-2 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Verkade, E. J. M.
Verhulst, C. J. M. M.
Huijsdens, X. W.
Kluytmans, J. A. J. W.
In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains
title In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains
title_full In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains
title_fullStr In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains
title_full_unstemmed In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains
title_short In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains
title_sort in vitro activity of tigecycline against methicillin-resistant staphylococcus aureus, including livestock-associated strains
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854363/
https://www.ncbi.nlm.nih.gov/pubmed/20186450
http://dx.doi.org/10.1007/s10096-010-0886-2
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