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AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

Excitotoxicity after glutamate receptor overactivation induces disturbances in cellular ion gradients, resulting in necrosis or apoptosis. Excitotoxic necrosis is triggered by rapid, irreversible ATP depletion, whereas the ability to recover cellular bioenergetics is suggested to be necessary for th...

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Detalles Bibliográficos
Autores principales:	Concannon, Caoimhín G., Tuffy, Liam P., Weisová, Petronela, Bonner, Helena P., Dávila, David, Bonner, Caroline, Devocelle, Marc C., Strasser, Andreas, Ward, Manus W., Prehn, Jochen H.M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854380/ https://www.ncbi.nlm.nih.gov/pubmed/20351066 http://dx.doi.org/10.1083/jcb.200909166

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