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Role of C-Reactive Protein in Contributing to Increased Cardiovascular Risk in Metabolic Syndrome

Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events....

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Detalles Bibliográficos
Autores principales: Devaraj, Sridevi, Valleggi, Simona, Siegel, David, Jialal, Ishwarlal
Formato: Texto
Lenguaje:English
Publicado: Current Science Inc. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854398/
https://www.ncbi.nlm.nih.gov/pubmed/20425246
http://dx.doi.org/10.1007/s11883-010-0098-3
Descripción
Sumario:Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.