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WSTF regulates the function of H2A.X via a novel tyrosine kinase activity

DNA double-stranded breaks present a serious challenge for eukaryotic cells. Inability to repair breaks leads to genomic instability, carcinogenesis, and cell death. During the DSB response, mammalian chromatin undergoes reorganization demarcated by H2A.X Ser139 phosphorylation (γ-H2A.X). However, t...

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Detalles Bibliográficos
Autores principales:	Xiao, Andrew, Li, Haitao, Shechter, David, Ahn, Sung Hee, Fabrizio, Laura A., Erdjument-Bromage, Hediye, Ishibe-Murakami, Satoko, Wang, Bin, Tempst, Paul, Hofmann, Kay, Patel, Dinshaw J., Elledge, Stephen J., Allis, C. David
Formato:	Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854499/ https://www.ncbi.nlm.nih.gov/pubmed/19092802 http://dx.doi.org/10.1038/nature07668

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