Role of BCR-ABL-Y177 mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors

In chronic myelogenous leukemia (CML) hematopoietic stem cell transformation leads to increased proliferation of malignant myeloid progenitors. The cyclin-dependent kinase inhibitor p27kip1 (p27) is a critical negative regulator of hematopoietic progenitor proliferation and pool size that is deregul...

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Detalles Bibliográficos
Autores principales: Chu, Su, McDonald, Tinisha, Bhatia, Ravi
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854856/
https://www.ncbi.nlm.nih.gov/pubmed/20200561
http://dx.doi.org/10.1038/leu.2010.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854856/
https://www.ncbi.nlm.nih.gov/pubmed/20200561
http://dx.doi.org/10.1038/leu.2010.24

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