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Current Issues in Migraine Genetics

Migraine often runs in families and is associated with both genetic and environmental factors. Clinical and genetic heterogeneity as well as the influence of environmental factors have hampered the identification of the gene responsible for migraine disorder. Family/twin studies suggest the presence...

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Detalles Bibliográficos
Autores principales: Lee, Jee-Young, Kim, Manho
Formato: Texto
Lenguaje:English
Publicado: Korean Neurological Association 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854934/
https://www.ncbi.nlm.nih.gov/pubmed/20396468
http://dx.doi.org/10.3988/jcn.2005.1.1.8
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author Lee, Jee-Young
Kim, Manho
author_facet Lee, Jee-Young
Kim, Manho
author_sort Lee, Jee-Young
collection PubMed
description Migraine often runs in families and is associated with both genetic and environmental factors. Clinical and genetic heterogeneity as well as the influence of environmental factors have hampered the identification of the gene responsible for migraine disorder. Family/twin studies suggest the presence of hereditary susceptibility. Several different types of mutations or association studies with genetic polymorphism in neurotransmitters, inflammatory cytokines, homocysteine metabolism, mitochondria, or other risk genes in cerebrovascular disorders have been reported. Recently, progress of molecular genetics in familial hemiplegic migraine has provided important insights, a channelopathy, and now extending to a growing list of membrane excitability disorders. Further identification of candidate genes for migraine and exploring the correlation between phenotype and genotype are expected in the future for the understanding of migraine pathophysiology.
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spelling pubmed-28549342010-04-15 Current Issues in Migraine Genetics Lee, Jee-Young Kim, Manho J Clin Neurol Review Migraine often runs in families and is associated with both genetic and environmental factors. Clinical and genetic heterogeneity as well as the influence of environmental factors have hampered the identification of the gene responsible for migraine disorder. Family/twin studies suggest the presence of hereditary susceptibility. Several different types of mutations or association studies with genetic polymorphism in neurotransmitters, inflammatory cytokines, homocysteine metabolism, mitochondria, or other risk genes in cerebrovascular disorders have been reported. Recently, progress of molecular genetics in familial hemiplegic migraine has provided important insights, a channelopathy, and now extending to a growing list of membrane excitability disorders. Further identification of candidate genes for migraine and exploring the correlation between phenotype and genotype are expected in the future for the understanding of migraine pathophysiology. Korean Neurological Association 2005-04 2005-04-30 /pmc/articles/PMC2854934/ /pubmed/20396468 http://dx.doi.org/10.3988/jcn.2005.1.1.8 Text en Copyright © 2005 Korean Neurological Association
spellingShingle Review
Lee, Jee-Young
Kim, Manho
Current Issues in Migraine Genetics
title Current Issues in Migraine Genetics
title_full Current Issues in Migraine Genetics
title_fullStr Current Issues in Migraine Genetics
title_full_unstemmed Current Issues in Migraine Genetics
title_short Current Issues in Migraine Genetics
title_sort current issues in migraine genetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854934/
https://www.ncbi.nlm.nih.gov/pubmed/20396468
http://dx.doi.org/10.3988/jcn.2005.1.1.8
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