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The Clinical and Electrophysiological Characteristics of Temporal Lobe Epilepsy with Normal MRI
BACKGROUND AND PURPOSE: To identify the clinical and electrophysiological characteristics of temporal lobe epilepsy (TLE) with normal MRI. METHODS: Twenty-six patients were diagnosed with TLE with normal MRI by stereotaxically implanted depth electrode EEG (SEEG) and quantitative MRI. We divided the...
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Formato: | Texto |
Lenguaje: | English |
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Korean Neurological Association
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854942/ https://www.ncbi.nlm.nih.gov/pubmed/20396484 http://dx.doi.org/10.3988/jcn.2006.2.1.42 |
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author | Kim, S.E. Andermann, F. Olivier, A. |
author_facet | Kim, S.E. Andermann, F. Olivier, A. |
author_sort | Kim, S.E. |
collection | PubMed |
description | BACKGROUND AND PURPOSE: To identify the clinical and electrophysiological characteristics of temporal lobe epilepsy (TLE) with normal MRI. METHODS: Twenty-six patients were diagnosed with TLE with normal MRI by stereotaxically implanted depth electrode EEG (SEEG) and quantitative MRI. We divided the patients into anterior or diffuse temporal groups by interictal EEG, into localized, hemispheric or non-lateralized onset groups by ictal scalp EEG, and into focal or regional onset groups by SEEG. The clinical and electrophysiological characteristics were compared with those of 25 TLE patients with unilateral hippocampal atrophy (HA) on MRI. Four patients of TLE with unilateral HA also underwent SEEG. RESULTS: Patients in the normal MRI group showed a significantly higher frequency of secondarily generalization (225±235, median 160 vs 68±48, median 50, p<0.05), shorter duration of epilepsy (16±10 yrs vs 25.9±7.8 yrs, p<0.001), and less favorable surgical outcome (50% vs 88%, p <0.05) than patients in the unilateral HA group. Also, patients with normal MRI frequently showed diffuse temporal (50% vs 20%, p<0.05) discharges on interictal EEG. The ictal seizure patterns of patients with normal MRI showed less localization to one temporal lobe on scalp EEG (28% vs 65%, p<0.001) and a higher frequency of regional onset on SEEG (68% vs 8%, p<0.001) than patients with unilateral HA. CONCLUSIONS: The characteristics of TLE with normal MRI compared with TLE with unilateral HA are shorter duration of epilepsy, higher frequency of secondarily generalization, and less favorable surgical outcome, suggesting wider areas of temporal lobe involved compared with patients with unilateral HA. |
format | Text |
id | pubmed-2854942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-28549422010-04-15 The Clinical and Electrophysiological Characteristics of Temporal Lobe Epilepsy with Normal MRI Kim, S.E. Andermann, F. Olivier, A. J Clin Neurol Original Article BACKGROUND AND PURPOSE: To identify the clinical and electrophysiological characteristics of temporal lobe epilepsy (TLE) with normal MRI. METHODS: Twenty-six patients were diagnosed with TLE with normal MRI by stereotaxically implanted depth electrode EEG (SEEG) and quantitative MRI. We divided the patients into anterior or diffuse temporal groups by interictal EEG, into localized, hemispheric or non-lateralized onset groups by ictal scalp EEG, and into focal or regional onset groups by SEEG. The clinical and electrophysiological characteristics were compared with those of 25 TLE patients with unilateral hippocampal atrophy (HA) on MRI. Four patients of TLE with unilateral HA also underwent SEEG. RESULTS: Patients in the normal MRI group showed a significantly higher frequency of secondarily generalization (225±235, median 160 vs 68±48, median 50, p<0.05), shorter duration of epilepsy (16±10 yrs vs 25.9±7.8 yrs, p<0.001), and less favorable surgical outcome (50% vs 88%, p <0.05) than patients in the unilateral HA group. Also, patients with normal MRI frequently showed diffuse temporal (50% vs 20%, p<0.05) discharges on interictal EEG. The ictal seizure patterns of patients with normal MRI showed less localization to one temporal lobe on scalp EEG (28% vs 65%, p<0.001) and a higher frequency of regional onset on SEEG (68% vs 8%, p<0.001) than patients with unilateral HA. CONCLUSIONS: The characteristics of TLE with normal MRI compared with TLE with unilateral HA are shorter duration of epilepsy, higher frequency of secondarily generalization, and less favorable surgical outcome, suggesting wider areas of temporal lobe involved compared with patients with unilateral HA. Korean Neurological Association 2006-03 2006-03-20 /pmc/articles/PMC2854942/ /pubmed/20396484 http://dx.doi.org/10.3988/jcn.2006.2.1.42 Text en Copyright © 2006 Korean Neurological Association |
spellingShingle | Original Article Kim, S.E. Andermann, F. Olivier, A. The Clinical and Electrophysiological Characteristics of Temporal Lobe Epilepsy with Normal MRI |
title | The Clinical and Electrophysiological Characteristics of Temporal Lobe Epilepsy with Normal MRI |
title_full | The Clinical and Electrophysiological Characteristics of Temporal Lobe Epilepsy with Normal MRI |
title_fullStr | The Clinical and Electrophysiological Characteristics of Temporal Lobe Epilepsy with Normal MRI |
title_full_unstemmed | The Clinical and Electrophysiological Characteristics of Temporal Lobe Epilepsy with Normal MRI |
title_short | The Clinical and Electrophysiological Characteristics of Temporal Lobe Epilepsy with Normal MRI |
title_sort | clinical and electrophysiological characteristics of temporal lobe epilepsy with normal mri |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854942/ https://www.ncbi.nlm.nih.gov/pubmed/20396484 http://dx.doi.org/10.3988/jcn.2006.2.1.42 |
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