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Primary Diffuse Leptomeningeal Gliomatosis: Report of a Case Presenting with Chronic Meningitis

Neoplastic meningitis occurs in approximately 5% of patients with cancer. Primary diffuse leptomeningeal gliomatosis is a rare condition whereby a glioma arises from heterotopic cell nests in the leptomeninges. We report here a case presenting with clinical features similar to those of chronic infec...

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Detalles Bibliográficos
Autores principales: Kim, Sung-Hun, Jun, Dong-Chul, Park, Jin Se, Heo, Jae-Hyeok, Kim, Sung-Min, Kim, Juhan, Paek, Sun Ha, Kim, Manho
Formato: Texto
Lenguaje:English
Publicado: Korean Neurological Association 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854966/
https://www.ncbi.nlm.nih.gov/pubmed/20396508
http://dx.doi.org/10.3988/jcn.2006.2.3.202
Descripción
Sumario:Neoplastic meningitis occurs in approximately 5% of patients with cancer. Primary diffuse leptomeningeal gliomatosis is a rare condition whereby a glioma arises from heterotopic cell nests in the leptomeninges. We report here a case presenting with clinical features similar to those of chronic infectious meningitis without positive cerebrospinal fluid cytology. Neurological signs in our patient deteriorated progressively without responding to antitubercular, antiviral, or antibiotic therapy. Leptomeningeal biopsy sampling revealed the condition to be primary diffuse leptomeningeal gliomatosis.