The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice

RATIONALE: Mice lacking metabotropic glutamate receptors 5 (mGluR5) exhibit reduced glutamatergic function and behavioral abnormalities, including deficits in prepulse inhibition (PPI) of the startle response that may be relevant to schizophrenia. Thus, these mice are an animal model that may be use...

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Detalles Bibliográficos
Autores principales: Chen, Hwei-Hsien, Stoker, Astrid, Markou, Athina
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855017/
https://www.ncbi.nlm.nih.gov/pubmed/20217053
http://dx.doi.org/10.1007/s00213-010-1802-2

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