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Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice

Presenilins are the major causative genes of familial Alzheimer's disease (AD). Our previous study has demonstrated essential roles of presenilins in memory and neuronal survival. Here, we explore further how loss of presenilins results in age-related, progressive neurodegeneration in the adult...

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Detalles Bibliográficos
Autores principales:	Wines-Samuelson, Mary, Schulte, Eva C., Smith, Miriam J., Aoki, Chiye, Liu, Xinran, Kelleher, Raymond J., Shen, Jie
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855368/ https://www.ncbi.nlm.nih.gov/pubmed/20419112 http://dx.doi.org/10.1371/journal.pone.0010195

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