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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Therapeutics that are designed to engage RNA interference (RNAi) pathways have the potential to provide new, major ways of imparting therapy to patients.1,2 Fire et al. first demonstrated that long, double stranded RNAs mediate RNAi in Caenorhabditis elegans,3 and Elbashir et al. opened the pathway...
Autores principales: | Davis, Mark E., Zuckerman, Jonathan E., Choi, Chung Hang J., Seligson, David, Tolcher, Anthony, Alabi, Christopher A., Yen, Yun, Heidel, Jeremy D., Ribas, Antoni |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855406/ https://www.ncbi.nlm.nih.gov/pubmed/20305636 http://dx.doi.org/10.1038/nature08956 |
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